Reno Tahoe International offers nonstop service to 24 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| San Jose | SJC | USA | 302 km | 1h 10m | WN |
| San Francisco | SFO | USA | 309 km | 1h 18m | UA |
| Las Vegas | LAS | USA | 557 km | 1h 21m | WN, F9, NK |
| Burbank | BUR | USA | 602 km | 1h 20m | WN |
| Los Angeles | LAX | USA | 629 km | 1h 41m | UA, WN, DL |
| Long Beach | LGB | USA | 647 km | 1h 30m | WN |
| Salt Lake City | SLC | USA | 679 km | 1h 33m | DL |
| Portland | PDX | USA | 714 km | 1h 37m | AS |
| San Diego | SAN | USA | 786 km | 1h 35m | WN, AS |
| Seattle | SEA | USA | 905 km | 2h 2m | AS |
| Phoenix | PHX | USA | 968 km | 1h 49m | AA, WN, F9 |
| Denver | DEN | USA | 1,294 km | 2h 15m | UA, WN |
| Dallas | DFW | USA | 2,165 km | 3h 20m | AA |
| Dallas | DAL | USA | 2,183 km | 3h 10m | WN |
| Austin | AUS | USA | 2,261 km | 3h 10m | WN |
| Minneapolis | MSP | USA | 2,262 km | 3h 13m | DL, SY |
| Houston | IAH | USA | 2,463 km | 3h 41m | UA |
| Guadalajara | GDL | Mexico | 2,626 km | 3h 46m | Y4 |
| Chicago | ORD | USA | 2,690 km | 3h 58m | UA |
| Chicago | MDW | USA | 2,705 km | 3h 40m | WN |
| Nashville | BNA | USA | 2,922 km | 4h 3m | WN |
| Atlanta | ATL | USA | 3,207 km | 4h 24m | DL |
| New York | JFK | USA | 3,879 km | 5h 4m | B6 |
| Fort Lauderdale | FLL | USA | 3,961 km | 5h 8m | B6 |