Spokane International offers nonstop service to 44 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Seattle | SEA | USA | 359 km | 1h 17m | AS, DL |
| Portland | PDX | USA | 448 km | 1h 14m | AS |
| Boise | BOI | USA | 462 km | 1h 11m | AS |
| Salt Lake City | SLC | USA | 879 km | 1h 51m | DL |
| Sacramento | SMF | USA | 1,045 km | 1h 55m | WN |
| Oakland | OAK | USA | 1,165 km | 2h 10m | WN |
| San Francisco | SFO | USA | 1,180 km | 2h 23m | AS, UA |
| San Jose | SJC | USA | 1,194 km | 2h 15m | WN |
| Las Vegas | LAS | USA | 1,297 km | 2h 20m | G4, WN |
| Denver | DEN | USA | 1,345 km | 2h 15m | UA, WN |
| Los Angeles | LAX | USA | 1,521 km | 2h 53m | AS, DL |
| Santa Ana | SNA | USA | 1,548 km | 2h 46m | AS |
| Phoenix | PHX | USA | 1,642 km | 2h 40m | AA, WN |
| San Diego | SAN | USA | 1,653 km | 2h 50m | AS, WN |
| Mesa | AZA | USA | 1,665 km | 2h 45m | G4 |
| Minneapolis | MSP | USA | 1,892 km | 2h 53m | DL |
| Dallas | DFW | USA | 2,376 km | 3h 42m | AA |
| Chicago | ORD | USA | 2,410 km | 3h 52m | AA, UA |
| Chicago | MDW | USA | 2,432 km | 3h 30m | WN |
| Anchorage | ANC | USA | 2,549 km | 3h 55m | AS |
| Atlanta | ATL | USA | 3,167 km | 4h 19m | DL |
| Honolulu | HNL | USA | 4,636 km | 7h 3m | AS |