Spokane International offers nonstop service to 23 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Seattle | SEA | USA | 359 km | 1h 17m | AS, DL |
| Portland | PDX | USA | 448 km | 1h 13m | AS |
| Boise | BOI | USA | 462 km | 1h 8m | AS |
| Salt Lake City | SLC | USA | 879 km | 1h 50m | DL |
| Sacramento | SMF | USA | 1,045 km | 1h 55m | WN |
| Oakland | OAK | USA | 1,165 km | 2h 10m | WN |
| San Francisco | SFO | USA | 1,180 km | 2h 23m | UA, AS |
| San Jose | SJC | USA | 1,194 km | 2h 10m | WN |
| Las Vegas | LAS | USA | 1,297 km | 2h 20m | WN, G4 |
| Denver | DEN | USA | 1,345 km | 2h 17m | F9, UA, WN |
| Los Angeles | LAX | USA | 1,521 km | 2h 52m | DL, AS |
| Santa Ana | SNA | USA | 1,548 km | 2h 44m | G4, AS |
| Phoenix | PHX | USA | 1,642 km | 2h 38m | AA, WN, F9 |
| San Diego | SAN | USA | 1,653 km | 2h 49m | AS, WN |
| Mesa | AZA | USA | 1,665 km | 2h 41m | G4 |
| Minneapolis | MSP | USA | 1,892 km | 2h 52m | DL, SY |
| Dallas | DFW | USA | 2,376 km | 3h 40m | AA |
| Dallas | DAL | USA | 2,392 km | 3h 25m | WN |
| Chicago | ORD | USA | 2,410 km | 3h 49m | UA, AA |
| Chicago | MDW | USA | 2,432 km | 3h 30m | WN |
| Anchorage | ANC | USA | 2,549 km | 3h 55m | AS |
| Houston | IAH | USA | 2,729 km | 4h 20m | UA |
| Atlanta | ATL | USA | 3,167 km | 4h 22m | DL |