Lihue offers nonstop service to 28 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Honolulu | HNL | USA | 164 km | 0h 39m | AS, WN |
| Kahului | OGG | USA | 324 km | 0h 51m | AS, WN |
| Kailua-Kona | KOA | USA | 424 km | 0h 54m | AS |
| San Francisco | SFO | USA | 3,937 km | 5h 14m | AS, UA |
| Oakland | OAK | USA | 3,955 km | 5h 15m | AS, WN |
| San Jose | SJC | USA | 3,969 km | 5h 10m | AS |
| Sacramento | SMF | USA | 4,037 km | 5h 14m | AS |
| Los Angeles | LAX | USA | 4,209 km | 5h 37m | AA, AS, DL, UA, WN |
| Portland | PDX | USA | 4,234 km | 5h 33m | AS |
| San Diego | SAN | USA | 4,306 km | 5h 40m | AS, WN |
| Seattle | SEA | USA | 4,347 km | 5h 50m | AS, DL |
| Las Vegas | LAS | USA | 4,535 km | 5h 50m | WN |
| Phoenix | PHX | USA | 4,796 km | 6h 5m | AA |
| Denver | DEN | USA | 5,494 km | 6h 57m | UA |