Kona offers nonstop service to 40 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kamuela | MUE | USA | 50 km | 0h 31m | 9X |
| Kahului | OGG | USA | 134 km | 0h 38m | 9X, AS, WN |
| Honolulu | HNL | USA | 263 km | 0h 50m | AS, WN |
| Kauai Island | LIH | USA | 424 km | 0h 57m | AS |
| San Francisco | SFO | USA | 3,808 km | 5h 10m | AS, UA |
| San Jose | SJC | USA | 3,836 km | 5h 7m | AS |
| Sacramento | SMF | USA | 3,918 km | 5h 13m | AS, WN |
| Los Angeles | LAX | USA | 4,029 km | 5h 27m | AA, AS, DL, UA, WN |
| San Diego | SAN | USA | 4,111 km | 5h 29m | AS, WN |
| Portland | PDX | USA | 4,195 km | 5h 38m | AS |
| Seattle | SEA | USA | 4,325 km | 5h 55m | AS, DL |
| Las Vegas | LAS | USA | 4,373 km | 5h 40m | WN |
| Vancouver | YVR | Canada | 4,384 km | 6h 0m | AC, WS |
| Phoenix | PHX | USA | 4,603 km | 5h 51m | AA |
| Anchorage | ANC | USA | 4,626 km | 6h 14m | AS |
| Salt Lake City | SLC | USA | 4,772 km | 6h 5m | DL |
| Calgary | YYC | Canada | 5,053 km | 6h 40m | WS |
| Denver | DEN | USA | 5,356 km | 6h 57m | UA |
| Dallas | DFW | USA | 5,992 km | 7h 30m | AA |
| Chicago | ORD | USA | 6,780 km | 8h 0m | UA |