John Wayne Arpt Orange Co offers nonstop service to 49 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Las Vegas | LAS | USA | 363 km | 1h 14m | DL, WN, F9, NK, MX |
| Phoenix | PHX | USA | 544 km | 1h 23m | AA, WN, F9 |
| San Jose | SJC | USA | 550 km | 1h 20m | WN |
| Mesa | AZA | USA | 578 km | 1h 26m | G4 |
| Oakland | OAK | USA | 595 km | 1h 25m | WN |
| San Francisco | SFO | USA | 598 km | 1h 38m | AS, UA, F9 |
| Sacramento | SMF | USA | 649 km | 1h 30m | WN |
| Tucson | TUS | USA | 670 km | 1h 32m | AS |
| Santa Rosa | STS | USA | 696 km | 1h 48m | AS |
| Provo | PVU | USA | 907 km | 1h 44m | G4, MX |
| Salt Lake City | SLC | USA | 945 km | 1h 55m | DL, F9 |
| Ogden | OGD | USA | 981 km | 1h 55m | MX |
| Grand Junction | GJT | USA | 1,031 km | 1h 58m | MX |
| Montrose | MTJ | USA | 1,044 km | 2h 3m | MX |
| Medford | MFR | USA | 1,059 km | 1h 59m | G4 |
| Boise | BOI | USA | 1,106 km | 2h 8m | G4, AS |
| Idaho Falls | IDA | USA | 1,201 km | 2h 7m | G4 |
| Eugene | EUG | USA | 1,248 km | 2h 11m | G4 |
| Colorado Springs | COS | USA | 1,310 km | 2h 17m | G4 |
| Denver | DEN | USA | 1,359 km | 2h 20m | F9, UA, WN |
| Portland | PDX | USA | 1,382 km | 2h 33m | AS |
| Pasco | PSC | USA | 1,400 km | 2h 22m | G4 |
| San Jose Cabo | SJD | Mexico | 1,411 km | 2h 20m | WN |
| Missoula | MSO | USA | 1,504 km | 2h 28m | G4 |
| Spokane | GEG | USA | 1,548 km | 2h 36m | G4, AS |
| Seattle | SEA | USA | 1,573 km | 2h 59m | AS, DL |
| Everett | PAE | USA | 1,623 km | 2h 44m | AS |
| Vancouver | YVR | Canada | 1,778 km | 3h 2m | AC |
| Puerto Vallarta | PVR | Mexico | 1,903 km | 2h 48m | WN |
| Dallas | DFW | USA | 1,938 km | 3h 6m | AA |
| Austin | AUS | USA | 1,944 km | 2h 50m | WN |
| Dallas | DAL | USA | 1,956 km | 3h 0m | WN |
| Calgary | YYC | Canada | 1,963 km | 3h 10m | WS |
| Houston | IAH | USA | 2,166 km | 3h 14m | UA |
| Des Moines | DSM | USA | 2,298 km | 3h 17m | G4 |
| Minneapolis | MSP | USA | 2,449 km | 3h 40m | DL |
| Chicago | ORD | USA | 2,776 km | 4h 14m | AA, UA |
| Appleton | ATW | USA | 2,781 km | 3h 49m | G4 |
| Louisville | SDF | USA | 2,926 km | 4h 39m | AA |
| Grand Rapids | GRR | USA | 2,985 km | 4h 5m | G4 |
| Cincinnati | CVG | USA | 3,021 km | 4h 19m | G4 |
| Atlanta | ATL | USA | 3,085 km | 4h 15m | DL |
| Detroit | DTW | USA | 3,152 km | 4h 19m | DL |
| Columbus | CMH | USA | 3,176 km | 4h 33m | MX |
| Charlotte | CLT | USA | 3,377 km | 4h 44m | AA |
| Orlando | MCO | USA | 3,518 km | 5h 6m | MX |
| Raleigh/Durham | RDU | USA | 3,560 km | 5h 5m | MX |
| New York | EWR | USA | 3,914 km | 5h 27m | UA |
| New York | JFK | USA | 3,947 km | 5h 30m | DL, AA |