John Wayne Arpt Orange Co offers nonstop service to 82 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Las Vegas | LAS | USA | 363 km | 1h 10m | AS, DL, F9, MX, WN |
| Phoenix | PHX | USA | 544 km | 1h 20m | AA, F9, WN |
| San Jose | SJC | USA | 550 km | 1h 20m | WN |
| Mesa | AZA | USA | 578 km | 1h 29m | G4 |
| Oakland | OAK | USA | 595 km | 1h 30m | WN |
| San Francisco | SFO | USA | 598 km | 1h 39m | AS, F9, UA |
| Sacramento | SMF | USA | 649 km | 1h 30m | WN |
| Tucson | TUS | USA | 670 km | 1h 32m | AS |
| Santa Rosa | STS | USA | 696 km | 1h 50m | AS |
| Provo | PVU | USA | 907 km | 1h 44m | G4, MX |
| Salt Lake City | SLC | USA | 945 km | 1h 56m | DL |
| Ogden | OGD | USA | 981 km | 1h 55m | MX |
| Medford | MFR | USA | 1,059 km | 2h 1m | G4 |
| Boise | BOI | USA | 1,106 km | 2h 7m | AS, G4 |
| Idaho Falls | IDA | USA | 1,201 km | 2h 11m | G4 |
| Eugene | EUG | USA | 1,248 km | 2h 11m | G4 |
| Colorado Springs | COS | USA | 1,310 km | 2h 15m | G4 |
| Denver | DEN | USA | 1,359 km | 2h 20m | F9, UA, WN |
| Portland | PDX | USA | 1,382 km | 2h 27m | AS |
| Pasco | PSC | USA | 1,400 km | 2h 22m | G4 |
| San Jose Cabo | SJD | Mexico | 1,411 km | 2h 20m | WN |
| Spokane | GEG | USA | 1,548 km | 2h 44m | AS, G4 |
| Seattle | SEA | USA | 1,573 km | 2h 55m | AS, DL |
| Everett | PAE | USA | 1,623 km | 2h 44m | AS |
| Vancouver | YVR | Canada | 1,778 km | 3h 3m | AC |
| Puerto Vallarta | PVR | Mexico | 1,903 km | 2h 55m | WN |
| Dallas | DFW | USA | 1,938 km | 3h 11m | AA, F9 |
| Austin | AUS | USA | 1,944 km | 2h 50m | WN |
| Dallas | DAL | USA | 1,956 km | 2h 55m | WN |
| Calgary | YYC | Canada | 1,963 km | 3h 10m | WS |
| Houston | IAH | USA | 2,166 km | 3h 16m | UA |
| Des Moines | DSM | USA | 2,298 km | 3h 17m | G4 |
| Minneapolis | MSP | USA | 2,449 km | 3h 41m | DL |
| Chicago | ORD | USA | 2,776 km | 4h 15m | AA, UA |
| Appleton | ATW | USA | 2,781 km | 3h 49m | G4 |
| Atlanta | ATL | USA | 3,085 km | 4h 14m | DL |
| Detroit | DTW | USA | 3,152 km | 4h 19m | DL |
| Charlotte | CLT | USA | 3,377 km | 4h 47m | AA |
| Dulles | IAD | USA | 3,645 km | 4h 57m | UA |
| New York | EWR | USA | 3,914 km | 5h 15m | UA |
| New York | JFK | USA | 3,947 km | 5h 29m | AA, DL |