Rogue Valley Intl Medford offers nonstop service to 10 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Portland | PDX | USA | 358 km | 1h 0m | AS |
| San Francisco | SFO | USA | 529 km | 1h 26m | UA |
| Seattle | SEA | USA | 565 km | 1h 34m | AS, DL |
| Salt Lake City | SLC | USA | 924 km | 1h 52m | DL |
| Las Vegas | LAS | USA | 964 km | 1h 48m | G4 |
| Los Angeles | LAX | USA | 1,013 km | 2h 2m | AS |
| Santa Ana | SNA | USA | 1,059 km | 1h 59m | G4 |
| San Diego | SAN | USA | 1,180 km | 2h 10m | AS |
| Phoenix | PHX | USA | 1,375 km | 2h 26m | AA |
| Denver | DEN | USA | 1,550 km | 2h 36m | UA |