Missoula Intl offers nonstop service to 13 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Seattle | SEA | USA | 625 km | 1h 40m | AS |
| Portland | PDX | USA | 672 km | 1h 35m | AS |
| Salt Lake City | SLC | USA | 702 km | 1h 42m | DL |
| Denver | DEN | USA | 1,092 km | 2h 7m | UA |
| Las Vegas | LAS | USA | 1,206 km | 2h 15m | G4 |
| San Francisco | SFO | USA | 1,238 km | 2h 35m | UA |
| Los Angeles | LAX | USA | 1,486 km | 3h 2m | UA, AA |
| Santa Ana | SNA | USA | 1,504 km | 2h 40m | G4 |
| Mesa | AZA | USA | 1,525 km | 2h 37m | G4 |
| San Diego | SAN | USA | 1,597 km | 2h 52m | AS |
| Minneapolis | MSP | USA | 1,630 km | 2h 41m | DL, SY |
| Dallas | DFW | USA | 2,123 km | 3h 31m | AA |
| Chicago | ORD | USA | 2,143 km | 3h 31m | AA, UA |