Missoula Intl offers nonstop service to 24 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Seattle | SEA | USA | 625 km | 1h 42m | AS |
| Portland | PDX | USA | 672 km | 1h 42m | AS |
| Salt Lake City | SLC | USA | 702 km | 1h 41m | DL |
| Denver | DEN | USA | 1,092 km | 2h 8m | UA |
| Las Vegas | LAS | USA | 1,206 km | 2h 15m | G4 |
| San Francisco | SFO | USA | 1,238 km | 2h 31m | UA |
| Los Angeles | LAX | USA | 1,486 km | 2h 56m | AA, UA |
| Mesa | AZA | USA | 1,525 km | 2h 40m | G4 |
| San Diego | SAN | USA | 1,597 km | 2h 52m | AS |
| Minneapolis | MSP | USA | 1,630 km | 2h 39m | DL |
| Dallas | DFW | USA | 2,123 km | 3h 27m | AA |
| Chicago | ORD | USA | 2,143 km | 3h 39m | AA, UA |