Tri Cities Airport offers nonstop service to 22 destinations, served by 5 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Seattle | SEA | USA | 276 km | 1h 14m | AS, DL |
| Portland | PDX | USA | 279 km | 0h 54m | AS |
| Salt Lake City | SLC | USA | 837 km | 1h 45m | DL |
| San Francisco | SFO | USA | 997 km | 2h 13m | UA |
| Las Vegas | LAS | USA | 1,177 km | 2h 11m | G4 |
| Los Angeles | LAX | USA | 1,368 km | 2h 50m | AS |
| Denver | DEN | USA | 1,372 km | 2h 22m | UA |
| Santa Ana | SNA | USA | 1,400 km | 2h 28m | G4 |
| Phoenix | PHX | USA | 1,547 km | 2h 47m | AA |
| Mesa | AZA | USA | 1,571 km | 2h 37m | G4 |
| Minneapolis | MSP | USA | 2,018 km | 3h 0m | DL |