Fairbanks International offers nonstop service to 30 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Fort Yukon | FYU | USA | 228 km | 0h 55m | 5V |
| Venetie | VEE | USA | 253 km | 1h 0m | 5V |
| Allakaket | AET | USA | 291 km | 0h 30m | 5V |
| Eagle | EAA | USA | 319 km | 1h 15m | 5V |
| Arctic Village | ARC | USA | 384 km | 1h 30m | 5V |
| Anaktuvuk | AKP | USA | 408 km | 1h 0m | 5V |
| Anchorage | ANC | USA | 420 km | 1h 9m | AS |
| Galena | GAL | USA | 431 km | 1h 5m | 5V |
| Barter Island | BTI | USA | 620 km | 1h 30m | 5V |
| Seattle | SEA | USA | 2,468 km | 3h 46m | AS, DL |
| Portland | PDX | USA | 2,639 km | 3h 51m | AS |
| Denver | DEN | USA | 3,911 km | 5h 15m | UA |
| Minneapolis | MSP | USA | 3,969 km | 5h 18m | DL |
| Chicago | ORD | USA | 4,482 km | 6h 4m | UA |