Ottawa Macdonald Cartier International offers nonstop service to 44 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Montreal | YUL | Canada | 151 km | 0h 49m | AC, TS, PP |
| Toronto | YTZ | Canada | 350 km | 1h 8m | PD, AC |
| Toronto | YYZ | Canada | 362 km | 1h 10m | AC, WS, PD |
| Quebec | YQB | Canada | 369 km | 1h 1m | AC |
| Sudbury | YSB | Canada | 422 km | 1h 15m | PP, PD |
| Boston | BOS | USA | 497 km | 1h 27m | PD |
| New York | EWR | USA | 528 km | 1h 33m | UA, PD |
| Windsor | YQG | Canada | 677 km | 1h 46m | PD |
| Fredericton | YFC | Canada | 715 km | 1h 25m | AC, PD |
| Dulles | IAD | USA | 722 km | 1h 49m | UA |
| Washington | DCA | USA | 727 km | 1h 49m | AC |
| Moncton | YQM | Canada | 859 km | 1h 43m | AC, PD |
| Halifax | YHZ | Canada | 957 km | 1h 59m | AC, PD |
| Charlottetown | YYG | Canada | 979 km | 1h 57m | PD |
| Chicago | ORD | USA | 1,053 km | 2h 32m | UA |
| Thunder Bay | YQT | Canada | 1,092 km | 2h 29m | PD |
| Deer Lake | YDF | Canada | 1,444 km | 2h 20m | PD |
| Kuujjuaq | YVP | Canada | 1,505 km | 2h 15m | 5T |
| Winnipeg | YWG | Canada | 1,691 km | 2h 50m | AC, WS, PD |
| St. John's | YYT | Canada | 1,772 km | 2h 38m | PD |
| Orlando | MCO | USA | 1,939 km | 3h 28m | AC, PD |
| Tampa | TPA | USA | 2,017 km | 3h 21m | PD |
| Iqaluit | YFB | Canada | 2,099 km | 3h 10m | 5T |
| Fort Myers | RSW | USA | 2,154 km | 3h 37m | PD |
| Fort Lauderdale | FLL | USA | 2,172 km | 3h 41m | AC, PD |
| Miami | MIA | USA | 2,205 km | 3h 45m | PD |
| Nassau | NAS | Bahamas | 2,254 km | 3h 50m | AC, PD |
| Edmonton | YEG | Canada | 2,857 km | 4h 25m | WS, PD |
| Puerto Plata | POP | Dominican Republic | 2,874 km | 4h 20m | TS |
| Cancun | CUN | Mexico | 2,881 km | 4h 30m | AC, TS, PD |
| Calgary | YYC | Canada | 2,885 km | 4h 30m | AC, WS, PD |
| Grand Cayman Island | GCM | Cayman Islands | 2,933 km | 4h 25m | PD |
| Montego Bay | MBJ | Jamaica | 2,981 km | 4h 45m | AC |
| Punta Cana | PUJ | Dominican Republic | 3,043 km | 4h 30m | AC, TS |
| Yellowknife | YZF | Canada | 3,107 km | 4h 45m | 4N |
| Kelowna | YLW | Canada | 3,276 km | 4h 55m | PD |
| Phoenix | PHX | USA | 3,361 km | 5h 25m | PD |
| Vancouver | YVR | Canada | 3,561 km | 5h 19m | AC, PD |
| Victoria | YYJ | Canada | 3,592 km | 5h 35m | PD |
| Puerto Vallarta | PVR | Mexico | 3,845 km | 5h 50m | PD |
| Guanacaste | LIR | Costa Rica | 3,962 km | 5h 50m | PD |
| London | LHR | United Kingdom | 5,362 km | 6h 25m | AC |
| London | LGW | United Kingdom | 5,394 km | 7h 15m | TS |
| Paris | CDG | France | 5,676 km | 6h 50m | AF |