Quebec Jean Lesage International offers nonstop service to 76 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Montreal | YHU | Canada | 211 km | 0h 45m | DU, P6 |
| Montreal | YUL | Canada | 235 km | 0h 55m | 3H, 9M, AC, PB, PP, TS |
| Baie Comeau | YBC | Canada | 352 km | 1h 0m | 9M, DU |
| Ottawa | YOW | Canada | 369 km | 1h 7m | AC |
| Bathurst | ZBF | Canada | 437 km | 1h 0m | PP |
| Val D'Or | YVO | Canada | 503 km | 1h 20m | DU |
| Sept-Iles | YZV | Canada | 536 km | 1h 20m | 3H, 9M, DU, PB |
| Gaspe | YGP | Canada | 562 km | 1h 33m | P6, PB |
| Rouyn | YUY | Canada | 582 km | 1h 35m | PP |
| New York | JFK | USA | 710 km | 1h 57m | AA |
| New York | EWR | USA | 714 km | 1h 50m | UA |
| Toronto | YTZ | Canada | 720 km | 1h 43m | PD |
| Iles De La Madeleine | YGR | Canada | 722 km | 1h 45m | P6 |
| Toronto | YYZ | Canada | 732 km | 1h 40m | AC, PD |
| Philadelphia | PHL | USA | 829 km | 2h 0m | AA |
| Dulles | IAD | USA | 1,001 km | 2h 10m | UA |
| Kuujjuaq | YVP | Canada | 1,274 km | 2h 5m | 3H |
| Chicago | ORD | USA | 1,417 km | 3h 5m | AA, UA |
| Charlotte | CLT | USA | 1,513 km | 2h 43m | AA |
| Orlando | MCO | USA | 2,213 km | 3h 55m | AC |
| Fort Lauderdale | FLL | USA | 2,426 km | 4h 0m | AC, TS |
| Dallas | DFW | USA | 2,663 km | 4h 8m | AA |
| Puerto Plata | POP | Dominican Republic | 2,999 km | 4h 20m | TS, WS |
| El Catey/Samana | AZS | Dominican Republic | 3,056 km | 4h 20m | TS |
| Calgary | YYC | Canada | 3,113 km | 4h 50m | WS |
| Punta Cana | PUJ | Dominican Republic | 3,143 km | 4h 35m | AC, TS |
| Cancun | CUN | Mexico | 3,182 km | 4h 55m | AC, TS |
| TULUM | TQO | Mexico | 3,302 km | 5h 10m | TS |
| Pointe-a-Pitre | PTP | Guadeloupe | 3,505 km | 4h 48m | AC, TS |
| Roatan | RTB | Honduras | 3,657 km | 5h 50m | WS |
| Fort De France | FDF | Martinique | 3,698 km | 5h 0m | AC, TS |
| Vancouver | YVR | Canada | 3,798 km | 5h 34m | AC |
| Puerto Vallarta | PVR | Mexico | 4,212 km | 6h 30m | TS |
| San Jose | SJO | Costa Rica | 4,255 km | 6h 10m | TS |
| Rio Hato | RIH | Panama | 4,339 km | 6h 13m | TS, WS |
| Nantes | NTE | France | 5,123 km | 6h 10m | TS |
| Paris | CDG | France | 5,308 km | 6h 30m | AF, TS |
| Marseille | MRS | France | 5,792 km | 7h 0m | TS |