St Johns International offers nonstop service to 37 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Gander | YQX | Canada | 200 km | 0h 50m | PB |
| Saint Pierre | FSP | St. Pierre and Miquelon | 276 km | 0h 45m | PJ |
| Deer Lake | YDF | Canada | 387 km | 1h 15m | PB |
| Saint Anthony | YAY | Canada | 465 km | 1h 30m | PB |
| Goose Bay | YYR | Canada | 834 km | 1h 55m | PB |
| Halifax | YHZ | Canada | 883 km | 2h 9m | AC, PD |
| Montreal | YHU | Canada | 1,597 km | 2h 50m | PD |
| Montreal | YUL | Canada | 1,624 km | 2h 52m | AC |
| Ottawa | YOW | Canada | 1,772 km | 3h 15m | PD |
| Toronto | YYZ | Canada | 2,128 km | 3h 42m | AC, F8, PD, WS |
| Hamilton | YHM | Canada | 2,173 km | 3h 35m | PD |
| Winnipeg | YWG | Canada | 3,231 km | 5h 0m | WS |
| Dublin | DUB | Ireland | 3,298 km | 4h 40m | WS |
| Tampa | TPA | USA | 3,374 km | 5h 30m | WS |
| London | LGW | United Kingdom | 3,755 km | 5h 15m | WS |
| Paris | CDG | France | 4,013 km | 5h 15m | WS |
| Edmonton | YEG | Canada | 4,233 km | 6h 10m | WS |
| Calgary | YYC | Canada | 4,336 km | 6h 20m | WS |