Edmonton International Airport offers nonstop service to 53 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Calgary | YYC | Canada | 243 km | 1h 0m | AC, WS, 4N |
| Grande Prairie | YQU | Canada | 402 km | 1h 15m | WS |
| Fort McMurray | YMM | Canada | 402 km | 1h 18m | WS |
| Saskatoon | YXE | Canada | 482 km | 1h 15m | WS |
| Kelowna | YLW | Canada | 547 km | 1h 20m | F8, WS |
| Kamloops | YKA | Canada | 552 km | 1h 15m | WS |
| Prince George | YXS | Canada | 604 km | 1h 40m | 9M |
| Fort Chipewyan | YPY | Canada | 627 km | 1h 25m | 8T |
| High Level | YOJ | Canada | 632 km | 1h 40m | 9M |
| Regina | YQR | Canada | 692 km | 1h 35m | WS |
| Fort Smith | YSM | Canada | 753 km | 1h 35m | 8T |
| Vancouver | YXX | Canada | 776 km | 1h 35m | F8, WS |
| Vancouver | YVR | Canada | 810 km | 1h 45m | AC, F8, WS |
| Hay River | YHY | Canada | 849 km | 2h 0m | 8T |
| Nanaimo | YCD | Canada | 859 km | 2h 5m | WS |
| Victoria | YYJ | Canada | 863 km | 1h 45m | WS, F8 |
| Comox | YQQ | Canada | 881 km | 1h 45m | WS |
| Seattle | SEA | USA | 898 km | 1h 53m | AS |
| Terrace | YXT | Canada | 992 km | 2h 25m | WS |
| Yellowknife | YZF | Canada | 1,021 km | 1h 45m | 5T, AC, WS, 4N |
| Winnipeg | YWG | Canada | 1,191 km | 1h 55m | F8, WS |
| Salt Lake City | SLC | USA | 1,397 km | 2h 20m | WS |
| Whitehorse | YXY | Canada | 1,533 km | 2h 25m | 4N |
| Denver | DEN | USA | 1,641 km | 2h 49m | UA |
| Minneapolis | MSP | USA | 1,748 km | 2h 45m | WS |
| San Francisco | SFO | USA | 1,871 km | 3h 3m | AC |
| Las Vegas | LAS | USA | 1,918 km | 3h 10m | WS |
| Palm Springs | PSP | USA | 2,177 km | 3h 35m | WS |
| Los Angeles | LAX | USA | 2,185 km | 3h 35m | WS |
| Phoenix | PHX | USA | 2,211 km | 3h 25m | WS |
| Chicago | ORD | USA | 2,284 km | 3h 34m | UA |
| Kitchener | YKF | Canada | 2,660 km | 3h 40m | F8 |
| Toronto | YYZ | Canada | 2,697 km | 3h 47m | AC, F8, WS, PD |
| Hamilton | YHM | Canada | 2,708 km | 3h 43m | PD |
| Ottawa | YOW | Canada | 2,857 km | 3h 50m | WS, PD |
| Montreal | YUL | Canada | 2,977 km | 4h 10m | AC, PD |
| Houston | IAH | USA | 2,983 km | 4h 34m | UA |
| Atlanta | ATL | USA | 3,173 km | 4h 27m | WS |
| San Jose Cabo | SJD | Mexico | 3,362 km | 5h 0m | WS |
| Mazatlan | MZT | Mexico | 3,402 km | 4h 50m | WS |
| Moncton | YQM | Canada | 3,542 km | 4h 35m | WS |
| Charlottetown | YYG | Canada | 3,635 km | 4h 45m | WS |
| Puerto Vallarta | PVR | Mexico | 3,690 km | 5h 15m | WS, F8 |
| Halifax | YHZ | Canada | 3,692 km | 4h 45m | WS |
| Orlando | MCO | USA | 3,816 km | 5h 14m | WS |
| St. John's | YYT | Canada | 4,233 km | 5h 30m | WS |
| Cancun | CUN | Mexico | 4,242 km | 5h 54m | WS, AC |
| Huatulco | HUX | Mexico | 4,432 km | 6h 7m | WS |
| Montego Bay | MBJ | Jamaica | 4,932 km | 6h 29m | WS |
| Reykjavik | KEF | Iceland | 4,937 km | 6h 25m | WS |
| Kahului | OGG | USA | 5,111 km | 7h 23m | WS |
| Honolulu | HNL | USA | 5,160 km | 7h 21m | WS |
| Amsterdam | AMS | Netherlands | 6,977 km | 8h 35m | KL |