City Centre offers nonstop service to 34 destinations, served by 2 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Ottawa | YOW | Canada | 350 km | 0h 57m | AC, PD |
| Montreal | YUL | Canada | 492 km | 1h 15m | AC, PD |
| Sault Ste. Marie | YAM | Canada | 512 km | 1h 26m | PD |
| Montreal | YHU | Canada | 518 km | 1h 15m | PD |
| New York | EWR | USA | 540 km | 1h 25m | PD |
| Dulles | IAD | USA | 544 km | 1h 28m | AC, PD |
| New York | LGA | USA | 555 km | 1h 30m | AC |
| Timmins | YTS | Canada | 569 km | 1h 27m | PD |
| Boston | BOS | USA | 696 km | 1h 37m | AC, PD |
| Chicago | MDW | USA | 713 km | 1h 50m | PD |
| Chicago | ORD | USA | 719 km | 2h 5m | AC, PD |
| Quebec | YQB | Canada | 720 km | 1h 31m | PD |
| Thunder Bay | YQT | Canada | 930 km | 2h 14m | PD |
| Nashville | BNA | USA | 1,038 km | 2h 20m | PD |
| Fredericton | YFC | Canada | 1,047 km | 1h 57m | PD |
| Moncton | YQM | Canada | 1,192 km | 2h 7m | PD |
| Halifax | YHZ | Canada | 1,273 km | 2h 20m | PD |