Yellowknife offers nonstop service to 24 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Snare Lake | YFJ | Canada | 192 km | 0h 45m | 8T |
| Hay River | YHY | Canada | 195 km | 0h 30m | 5T, 8T |
| Lutselke/Snowdrift | YSG | Canada | 225 km | 0h 45m | 8T |
| Rae Lakes | YRA | Canada | 233 km | 0h 55m | 8T |
| Fort Smith | YSM | Canada | 303 km | 0h 40m | 8T |
| Fort Simpson | YFS | Canada | 363 km | 0h 55m | 8T, 5T |
| Deline | YWJ | Canada | 537 km | 1h 25m | HW |
| Kugluktuk/Coppermine | YCO | Canada | 598 km | 1h 30m | 5T |
| Tulita/Fort Norman | ZFN | Canada | 613 km | 1h 25m | HW |
| Norman Wells | YVQ | Canada | 681 km | 1h 20m | 5T |
| Colville Lake | YCK | Canada | 751 km | 1h 45m | HW |
| Fort Good Hope | YGH | Canada | 803 km | 1h 55m | HW |
| Cambridge Bay | YCB | Canada | 851 km | 2h 2m | 5T |
| Ulukhaktok | YHI | Canada | 936 km | 2h 26m | 5T |
| Edmonton | YEG | Canada | 1,021 km | 1h 40m | 5T, AC, WS, 4N |
| Gjoa Haven | YHK | Canada | 1,088 km | 2h 30m | 5T |
| Inuvik | YEV | Canada | 1,091 km | 1h 50m | 5T |
| Whitehorse | YXY | Canada | 1,107 km | 1h 55m | 4N |
| Rankin Inlet | YRT | Canada | 1,140 km | 2h 5m | 5T |
| Taloyoak | YYH | Canada | 1,222 km | 2h 45m | 5T |
| Calgary | YYC | Canada | 1,262 km | 2h 15m | WS |
| Vancouver | YVR | Canada | 1,573 km | 2h 45m | AC, 4N |
| Toronto | YYZ | Canada | 3,066 km | 4h 15m | 4N, AC |
| Ottawa | YOW | Canada | 3,107 km | 4h 10m | 4N |