Daniel Oduber Quiros International offers nonstop service to 60 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Nosara Beach | NOB | Costa Rica | 70 km | 0h 30m | GW |
| Cobano | ACO | Costa Rica | 111 km | 0h 30m | RZ |
| San Jose | SJO | Costa Rica | 160 km | 0h 50m | RZ |
| Miami | MIA | USA | 1,770 km | 3h 4m | AA |
| Fort Lauderdale | FLL | USA | 1,804 km | 2h 58m | B6 |
| Houston | HOU | USA | 2,338 km | 3h 35m | WN |
| Houston | IAH | USA | 2,374 km | 3h 43m | UA |
| Atlanta | ATL | USA | 2,553 km | 4h 0m | DL |
| Dallas | DFW | USA | 2,735 km | 4h 33m | AA |
| Charlotte | CLT | USA | 2,766 km | 4h 26m | AA |
| Nashville | BNA | USA | 2,830 km | 4h 20m | WN |
| Dulles | IAD | USA | 3,242 km | 4h 35m | UA |
| Baltimore | BWI | USA | 3,286 km | 4h 35m | WN |
| Philadelphia | PHL | USA | 3,399 km | 4h 52m | AA |
| Chicago | ORD | USA | 3,484 km | 5h 23m | AA, UA |
| Detroit | DTW | USA | 3,508 km | 5h 14m | DL |
| New York | EWR | USA | 3,516 km | 5h 5m | UA |
| New York | JFK | USA | 3,523 km | 5h 8m | AA, B6, DL |
| Toronto | YYZ | Canada | 3,710 km | 5h 25m | AC, PD, TS, WS |
| Denver | DEN | USA | 3,752 km | 5h 31m | UA, WN |
| Boston | BOS | USA | 3,793 km | 5h 25m | B6, DL |
| Minneapolis | MSP | USA | 3,870 km | 5h 35m | DL, SY |
| Ottawa | YOW | Canada | 3,962 km | 5h 29m | PD |
| Montreal | YUL | Canada | 4,023 km | 5h 30m | AC, TS |
| Los Angeles | LAX | USA | 4,227 km | 6h 6m | AS, UA |
| Winnipeg | YWG | Canada | 4,489 km | 6h 25m | WS |
| San Francisco | SFO | USA | 4,741 km | 6h 54m | AS, UA |
| Calgary | YYC | Canada | 5,187 km | 7h 20m | WS |
| Seattle | SEA | USA | 5,341 km | 7h 50m | AS |
| Vancouver | YVR | Canada | 5,511 km | 7h 55m | AC, WS |
| Zurich | ZRH | Switzerland | 9,455 km | 11h 0m | WK |