Hamilton offers nonstop service to 28 destinations, served by 2 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Ottawa | YOW | Canada | 415 km | 1h 10m | PD |
| Montreal | YHU | Canada | 580 km | 1h 29m | PD |
| Halifax | YHZ | Canada | 1,327 km | 2h 9m | PD |
| Winnipeg | YWG | Canada | 1,517 km | 2h 25m | PD |
| Orlando | MCO | USA | 1,640 km | 3h 5m | PD |
| Tampa | TPA | USA | 1,701 km | 3h 5m | PD |
| Fort Lauderdale | FLL | USA | 1,897 km | 3h 20m | PD |
| St. John's | YYT | Canada | 2,173 km | 3h 10m | PD |
| Cancun | CUN | Mexico | 2,538 km | 4h 10m | PD |
| Calgary | YYC | Canada | 2,703 km | 4h 25m | PD, WS |
| Edmonton | YEG | Canada | 2,708 km | 4h 12m | PD |
| Montego Bay | MBJ | Jamaica | 2,742 km | 4h 7m | PD |
| Vancouver | YVR | Canada | 3,357 km | 5h 27m | PD |
| Puerto Vallarta | PVR | Mexico | 3,430 km | 5h 21m | PD |