Hermanos Serdan International offers nonstop service to 34 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Acapulco | ACA | Mexico | 300 km | 0h 47m | Y4 |
| Puerto Escondido | PXM | Mexico | 388 km | 0h 55m | Y4 |
| Huatulco | HUX | Mexico | 436 km | 1h 1m | Y4 |
| Aguascalientes | AGU | Mexico | 500 km | 1h 12m | Y4 |
| Guadalajara | GDL | Mexico | 540 km | 1h 21m | VB, Y4 |
| Villahermosa | VSA | Mexico | 599 km | 1h 12m | Y4 |
| Tuxtla Gutierrez | TGZ | Mexico | 633 km | 1h 18m | Y4 |
| Puerto Vallarta | PVR | Mexico | 740 km | 1h 33m | Y4 |
| Monterrey | MTY | Mexico | 757 km | 1h 37m | VB |
| Merida | MID | Mexico | 931 km | 1h 40m | VB |
| Cancun | CUN | Mexico | 1,220 km | 2h 8m | VB, Y4 |
| Houston | IAH | USA | 1,239 km | 2h 21m | UA, Y4 |
| San Jose Cabo | SJD | Mexico | 1,259 km | 2h 11m | Y4 |
| Tijuana | TIJ | Mexico | 2,377 km | 3h 42m | VB, Y4 |
| Los Angeles | LAX | USA | 2,575 km | 4h 12m | Y4 |
| Chicago | ORD | USA | 2,718 km | 3h 51m | Y4 |
| New York | EWR | USA | 3,319 km | 4h 35m | Y4 |