General Rodolfo Sanchez Taboada International offers nonstop service to 18 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Hermosillo | HMO | Mexico | 561 km | 1h 12m | Y4 |
| Los Mochis | LMM | Mexico | 975 km | 1h 40m | Y4 |
| Culiacan | CUL | Mexico | 1,155 km | 1h 50m | Y4 |
| San Jose Cabo | SJD | Mexico | 1,181 km | 2h 0m | Y4 |
| Monterrey | MTY | Mexico | 1,653 km | 2h 35m | VB |
| Puerto Vallarta | PVR | Mexico | 1,654 km | 2h 36m | Y4 |
| Guadalajara | GDL | Mexico | 1,789 km | 2h 43m | Y4 |
| Leon/Guanajuato | BJX | Mexico | 1,876 km | 2h 42m | Y4 |
| Mexico City | MEX | Mexico | 2,175 km | 3h 20m | AM, Y4 |