Regina International offers nonstop service to 30 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Saskatoon | YXE | Canada | 239 km | 0h 46m | AC |
| Winnipeg | YWG | Canada | 533 km | 1h 30m | WS |
| Calgary | YYC | Canada | 663 km | 1h 45m | WS |
| Edmonton | YEG | Canada | 692 km | 1h 40m | WS |
| Kelowna | YLW | Canada | 1,051 km | 2h 20m | WS |
| Minneapolis | MSP | USA | 1,056 km | 2h 25m | WS |
| Denver | DEN | USA | 1,176 km | 2h 34m | UA |
| Vancouver | YVR | Canada | 1,336 km | 2h 21m | AC, WS |
| Phoenix | PHX | USA | 1,981 km | 3h 25m | WS |
| Toronto | YYZ | Canada | 2,033 km | 3h 0m | AC, WS |
| Mazatlan | MZT | Mexico | 3,029 km | 4h 45m | WS |
| San Jose Cabo | SJD | Mexico | 3,058 km | 4h 50m | WS |
| Halifax | YHZ | Canada | 3,109 km | 4h 10m | WS |
| Puerto Vallarta | PVR | Mexico | 3,302 km | 5h 5m | WS |
| Cancun | CUN | Mexico | 3,615 km | 5h 20m | WS |