Ingeniero F Espinoza Gutierrez International offers nonstop service to 50 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | MEX | Mexico | 175 km | 1h 6m | AM |
| Guadalajara | GDL | Mexico | 325 km | 0h 58m | Y4 |
| Ixtapa/Zihuatanejo | ZIH | Mexico | 359 km | 0h 59m | Y4 |
| Acapulco | ACA | Mexico | 429 km | 1h 5m | Y4, YQ |
| Veracruz | VER | Mexico | 450 km | 1h 8m | Y4 |
| Puerto Vallarta | PVR | Mexico | 527 km | 1h 21m | Y4 |
| Oaxaca | OAX | Mexico | 542 km | 1h 4m | Y4 |
| Monterrey | MTY | Mexico | 570 km | 1h 27m | VB, Y4 |
| Torreon | TRC | Mexico | 638 km | 1h 20m | YQ |
| Mazatlan | MZT | Mexico | 688 km | 1h 22m | Y4, YQ |
| San Antonio | SAT | USA | 1,001 km | 1h 46m | VB, Y4 |
| San Jose Cabo | SJD | Mexico | 1,023 km | 1h 53m | VB |
| Merida | MID | Mexico | 1,096 km | 1h 56m | VB |
| Houston | IAH | USA | 1,145 km | 2h 5m | UA, VB, Y4 |
| Cancun | CUN | Mexico | 1,386 km | 2h 21m | VB, Y4 |
| Dallas | DFW | USA | 1,395 km | 2h 39m | AA, VB, Y4 |
| Orlando | MCO | USA | 2,096 km | 3h 14m | Y4 |
| Atlanta | ATL | USA | 2,120 km | 3h 22m | AM |
| Tijuana | TIJ | Mexico | 2,125 km | 3h 17m | VB, Y4 |
| Denver | DEN | USA | 2,174 km | 3h 20m | Y4 |
| Las Vegas | LAS | USA | 2,249 km | 3h 38m | Y4 |
| Los Angeles | LAX | USA | 2,323 km | 3h 51m | Y4 |
| Chicago | ORD | USA | 2,634 km | 3h 57m | AA, Y4 |
| Detroit | DTW | USA | 2,867 km | 4h 14m | AM |
| Madrid | MAD | Spain | 9,085 km | 10h 50m | E9 |