Guanajuato offers nonstop service to 46 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Mexico City | NLU | Mexico | 291 km | 0h 56m | VB, XN |
| Mexico City | MEX | Mexico | 305 km | 1h 15m | AM |
| Puerto Vallarta | PVR | Mexico | 393 km | 1h 7m | Y4 |
| Monterrey | MTY | Mexico | 547 km | 1h 22m | VB, Y4 |
| San Jose Cabo | SJD | Mexico | 883 km | 1h 45m | Y4 |
| San Antonio | SAT | USA | 992 km | 1h 46m | VB |
| Houston | IAH | USA | 1,171 km | 2h 7m | UA, VB |
| Merida | MID | Mexico | 1,228 km | 2h 1m | VB |
| Ciudad Juarez | CJS | Mexico | 1,278 km | 2h 10m | VB |
| Dallas | DFW | USA | 1,390 km | 2h 34m | AA, VB |
| Cancun | CUN | Mexico | 1,517 km | 2h 30m | VB, Y4 |
| Mexicali | MXL | Mexico | 1,876 km | 2h 57m | Y4 |
| Tijuana | TIJ | Mexico | 1,998 km | 3h 8m | VB, Y4 |
| Ontario | ONT | USA | 2,146 km | 3h 25m | Y4 |
| Atlanta | ATL | USA | 2,186 km | 3h 31m | AM |
| Los Angeles | LAX | USA | 2,198 km | 3h 39m | Y4 |
| Fresno | FAT | USA | 2,485 km | 3h 45m | Y4 |
| Chicago | MDW | USA | 2,642 km | 3h 56m | Y4 |
| Chicago | ORD | USA | 2,652 km | 3h 58m | Y4 |
| San Jose | SJC | USA | 2,680 km | 4h 6m | Y4 |
| Oakland | OAK | USA | 2,723 km | 4h 12m | Y4 |
| Sacramento | SMF | USA | 2,749 km | 4h 18m | Y4 |
| Vancouver | YVR | Canada | 3,672 km | 5h 20m | F8 |