Ponciano Arriaga International offers nonstop service to 13 destinations, served by 8 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guadalajara | GDL | Mexico | 312 km | 1h 7m | Y4 |
| Mexico City | NLU | Mexico | 340 km | 1h 5m | ZV, VB |
| Mexico City | MEX | Mexico | 367 km | 1h 17m | AM, IB |
| Monterrey | MTY | Mexico | 398 km | 1h 29m | VB, ZV, Y4 |
| Puebla | PBC | Mexico | 436 km | 1h 9m | Y4 |
| Puerto Vallarta | PVR | Mexico | 480 km | 1h 10m | YQ, Y4 |
| San Antonio | SAT | USA | 842 km | 1h 31m | Y4 |
| Houston | IAH | USA | 1,022 km | 2h 1m | UA, Y4 |
| Dallas | DFW | USA | 1,240 km | 2h 17m | AA, Y4 |
| Cancun | CUN | Mexico | 1,460 km | 2h 13m | Y4 |
| Tijuana | TIJ | Mexico | 1,950 km | 2h 51m | Y4 |
| Atlanta | ATL | USA | 2,050 km | 3h 30m | AM |
| Chicago | MDW | USA | 2,492 km | 3h 37m | Y4 |