Ponciano Arriaga International offers nonstop service to 22 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guadalajara | GDL | Mexico | 312 km | 0h 53m | Y4 |
| Mexico City | NLU | Mexico | 340 km | 1h 4m | VB |
| Mexico City | MEX | Mexico | 367 km | 1h 16m | AM, IB |
| Monterrey | MTY | Mexico | 398 km | 1h 10m | VB, Y4, ZV |
| Puerto Vallarta | PVR | Mexico | 480 km | 1h 15m | Y4 |
| San Antonio | SAT | USA | 842 km | 1h 36m | Y4 |
| Houston | IAH | USA | 1,022 km | 2h 2m | UA, Y4 |
| Dallas | DFW | USA | 1,240 km | 2h 19m | AA, Y4 |
| Cancun | CUN | Mexico | 1,460 km | 2h 18m | Y4 |
| Tijuana | TIJ | Mexico | 1,950 km | 3h 2m | Y4 |
| Chicago | MDW | USA | 2,492 km | 3h 30m | Y4 |