Saskatoon J G Diefenbaker International offers nonstop service to 16 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Prince Albert | YPA | Canada | 135 km | 0h 30m | 4T |
| Edmonton | YEG | Canada | 482 km | 1h 22m | WS |
| Calgary | YYC | Canada | 519 km | 1h 20m | WS |
| Winnipeg | YWG | Canada | 709 km | 1h 36m | WS |
| Stony Rapids | YSF | Canada | 790 km | 2h 0m | 4T |
| Fond Du Lac | ZFD | Canada | 798 km | 2h 0m | 4T |
| Kelowna | YLW | Canada | 921 km | 2h 10m | WS |
| Vancouver | YVR | Canada | 1,208 km | 2h 15m | AC, WS |
| Minneapolis | MSP | USA | 1,280 km | 2h 20m | WS |
| Las Vegas | LAS | USA | 1,908 km | 3h 9m | WS |
| Phoenix | PHX | USA | 2,124 km | 3h 24m | WS |
| Toronto | YYZ | Canada | 2,215 km | 3h 13m | AC, WS, PD |
| Montreal | YUL | Canada | 2,507 km | 3h 31m | AC |
| Halifax | YHZ | Canada | 3,238 km | 4h 20m | WS |
| Puerto Vallarta | PVR | Mexico | 3,496 km | 5h 15m | WS |
| Cancun | CUN | Mexico | 3,854 km | 5h 38m | WS |