Huatulco offers nonstop service to 20 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Puebla | PBC | Mexico | 436 km | 1h 1m | Y4 |
| Mexico City | MEX | Mexico | 505 km | 1h 29m | AM, VB, Y4 |
| Mexico City | NLU | Mexico | 530 km | 1h 23m | VB |
| Monterrey | MTY | Mexico | 1,179 km | 2h 11m | VB |
| Dallas | DFW | USA | 1,899 km | 3h 23m | AA |
| Toronto | YYZ | Canada | 3,472 km | 5h 5m | AC, WS |
| Winnipeg | YWG | Canada | 3,787 km | 5h 30m | WS |
| Calgary | YYC | Canada | 4,231 km | 6h 15m | WS |
| Edmonton | YEG | Canada | 4,432 km | 6h 29m | WS |
| Vancouver | YVR | Canada | 4,439 km | 6h 40m | AC, WS |