General Rafael Buelna International offers nonstop service to 42 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cabo San Lucas | CSW | Mexico | 376 km | 0h 55m | SEN |
| Guadalajara | GDL | Mexico | 423 km | 1h 10m | Y4 |
| La Paz | LAP | Mexico | 430 km | 1h 0m | YQ |
| Chihuahua | CUU | Mexico | 614 km | 1h 15m | VB |
| Monterrey | MTY | Mexico | 687 km | 1h 27m | VB |
| Queretaro | QRO | Mexico | 688 km | 1h 20m | Y4, YQ |
| Mexico City | NLU | Mexico | 841 km | 1h 35m | VB, XN |
| Mexico City | MEX | Mexico | 853 km | 1h 50m | AM, VB, Y4 |
| Ciudad Juarez | CJS | Mexico | 938 km | 1h 43m | VB |
| Phoenix | PHX | USA | 1,268 km | 2h 20m | AA |
| Houston | IAH | USA | 1,323 km | 2h 21m | UA |
| Dallas | DFW | USA | 1,408 km | 2h 34m | AA |
| Tijuana | TIJ | Mexico | 1,478 km | 2h 28m | VB, Y4 |
| Los Angeles | LAX | USA | 1,681 km | 2h 52m | AS |
| Minneapolis | MSP | USA | 2,685 km | 3h 51m | SY |
| Regina | YQR | Canada | 3,029 km | 4h 25m | WS |
| Calgary | YYC | Canada | 3,174 km | 4h 45m | WS |
| Kelowna | YLW | Canada | 3,184 km | 4h 45m | WS |
| Saskatoon | YXE | Canada | 3,219 km | 4h 55m | WS |
| Vancouver | YVR | Canada | 3,247 km | 5h 0m | AC, WS |
| Edmonton | YEG | Canada | 3,402 km | 5h 5m | WS |