Jomo Kenyatta International offers nonstop service to 65 destinations, served by 33 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Kilimanjaro | JRO | United Republic of Tanzania | 233 km | 1h 0m | KQ, PW |
| Eldoret | EDL | Kenya | 268 km | 1h 0m | JM |
| Kisumu | KIS | Kenya | 279 km | 0h 50m | KQ, JM, F2, W2 |
| Malindi | MYD | Kenya | 411 km | 1h 15m | JM |
| Mombasa | MBA | Kenya | 422 km | 1h 0m | KQ, JM |
| Ukunda | UKA | Kenya | 441 km | 1h 15m | JM, F2, W2 |
| Lamu | LAU | Kenya | 455 km | 1h 20m | JM |
| Wajir | WJR | Kenya | 487 km | 1h 0m | |
| Entebbe | EBB | Uganda | 521 km | 1h 15m | KQ, UR, W2 |
| Zanzibar | ZNZ | United Republic of Tanzania | 598 km | 1h 20m | KQ, PW, TC |
| Kismayu | KMU | Somalia | 624 km | 1h 40m | |
| Dar Es Salaam | DAR | United Republic of Tanzania | 664 km | 1h 25m | KQ, PW, TC, ZN |
| Kigali | KGL | Rwanda | 758 km | 1h 30m | KQ, WB |
| Mandera | NDE | Kenya | 799 km | 2h 0m | |
| Bujumbura | BJM | Burundi | 874 km | 1h 40m | KQ |
| Juba | JUB | South Sudan | 904 km | 1h 45m | KQ |
| Mogadishu | MGQ | Somalia | 1,003 km | 1h 45m | W2 |
| Addis Ababa | ADD | Ethiopia | 1,158 km | 2h 0m | ET, KQ |
| Moroni | HAH | Comoros | 1,329 km | 2h 30m | KQ |
| Lilongwe | LLW | Malawi | 1,421 km | 2h 15m | ET, KQ |
| Hargeisa | HGA | Somalia | 1,437 km | 2h 0m | |
| Galcaio | GLK | Somalia | 1,470 km | 3h 0m | |
| Lubumbashi | FBM | The Democratic Republic of The Congo | 1,538 km | 2h 25m | KQ |
| Nampula | APL | Mozambique | 1,546 km | 2h 30m | KQ |
| Dzaoudzi | DZA | Mayotte | 1,569 km | 2h 30m | KQ |
| Ndola | NLA | Zambia | 1,586 km | 2h 40m | KQ |
| Garowe | GGR | Somalia | 1,685 km | 2h 45m | |
| Lusaka | LUN | Zambia | 1,807 km | 2h 45m | KQ, ZN |
| Harare | HRE | Zimbabwe | 1,943 km | 3h 0m | KQ |
| Mahe Island | SEZ | Seychelles | 2,098 km | 3h 15m | KQ |
| Livingstone | LVI | Zambia | 2,192 km | 3h 15m | KQ |
| Victoria Falls | VFA | Zimbabwe | 2,216 km | 3h 15m | KQ |
| Antananarivo | TNR | Madagascar | 2,250 km | 3h 20m | KQ |
| Kinshasa | FIH | The Democratic Republic of The Congo | 2,412 km | 3h 20m | KQ |
| Jeddah | JED | Saudi Arabia | 2,554 km | 3h 45m | SV |
| Luanda | NBJ | Angola | 2,732 km | 3h 58m | DT |
| Johannesburg | JNB | South Africa | 2,899 km | 4h 15m | KQ, 4Z |
| Douala | DLA | Cameroon | 3,083 km | 4h 10m | KQ |
| Mauritius | MRU | Mauritius | 3,092 km | 4h 20m | KQ |
| Riyadh | RUH | Saudi Arabia | 3,092 km | 4h 45m | XY |
| Hurghada | HRG | Egypt | 3,172 km | 5h 0m | SM |
| Doha | DOH | Qatar | 3,339 km | 5h 10m | QR |
| Bahrain | BAH | Bahrain | 3,389 km | 5h 10m | GF |
| Abu Dhabi | AUH | United Arab Emirates | 3,431 km | 5h 0m | EY |
| Cairo | CAI | Egypt | 3,528 km | 5h 10m | MS, SM |
| Dubai | DXB | United Arab Emirates | 3,549 km | 5h 15m | EK, KQ, FZ |
| Sharjah | SHJ | United Arab Emirates | 3,564 km | 5h 10m | G9, KQ |
| Muscat | MCT | Oman | 3,597 km | 5h 0m | OV |
| Lagos | LOS | Nigeria | 3,834 km | 5h 15m | KQ |
| Lome | LFW | Togo | 4,050 km | 5h 35m | KP |
| Cape Town | CPT | South Africa | 4,087 km | 5h 45m | KQ |
| Accra | ACC | Ghana | 4,194 km | 5h 38m | KQ |
| Mumbai | BOM | India | 4,531 km | 6h 20m | KQ, 6E |
| Abidjan | ABJ | Cote d'Ivoire | 4,600 km | 6h 5m | KQ |
| Istanbul | IST | Turkiye | 4,787 km | 6h 55m | TK |
| Frankfurt | FRA | Germany | 6,302 km | 8h 20m | LH |
| Paris | CDG | France | 6,479 km | 8h 55m | AF, KQ, UU |
| Brussels | BRU | Belgium | 6,551 km | 9h 0m | SN |
| Amsterdam | AMS | Netherlands | 6,662 km | 9h 0m | KL, KQ |
| London | LGW | United Kingdom | 6,788 km | 9h 10m | KQ |
| London | LHR | United Kingdom | 6,827 km | 9h 10m | BA, KQ |
| Bangkok | BKK | Thailand | 7,230 km | 9h 31m | KQ |
| Guangzhou | CAN | China | 8,684 km | 11h 15m | CZ |
| Changsha | CSX | China | 8,742 km | 10h 33m | CZ |
| New York | JFK | USA | 11,844 km | 15h 0m | KQ |