Cape Town International offers nonstop service to 82 destinations, served by 27 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| George | GRJ | South Africa | 349 km | 0h 55m | 4Z, FA |
| Port Elizabeth | PLZ | South Africa | 648 km | 1h 15m | 4Z, FA |
| Upington | UTN | South Africa | 667 km | 1h 15m | 4Z |
| Kimberley | KIM | South Africa | 819 km | 1h 35m | 4Z, 5Z |
| East London | ELS | South Africa | 863 km | 1h 35m | 5Z, FA |
| Bloemfontein | BFN | South Africa | 908 km | 1h 30m | 4Z, FA |
| Gaborone | GBE | Botswana | 1,262 km | 2h 0m | 4Z, BP |
| Lanseria | HLA | South Africa | 1,265 km | 2h 5m | FA |
| Johannesburg | JNB | South Africa | 1,271 km | 2h 0m | 4Z, 5Z, FA, GE, SA, SQ |
| Windhoek | WDH | Namibia | 1,277 km | 2h 10m | 4Z, FA |
| Walvis Bay | WVB | Namibia | 1,277 km | 2h 15m | 4Z |
| Durban | DUR | South Africa | 1,279 km | 2h 0m | 5Z, FA, GE, RN |
| Manzini | SHO | Eswatini | 1,517 km | 2h 30m | RN |
| Nelspruit | MQP | South Africa | 1,537 km | 2h 20m | 4Z, FA |
| Hoedspruit | HDS | South Africa | 1,604 km | 2h 30m | 4Z, 5Z, FA |
| Skukuza | SZK | South Africa | 1,605 km | 2h 25m | 4Z |
| Maputo | MPM | Mozambique | 1,614 km | 2h 30m | 4Z |
| Maun | MUB | Botswana | 1,622 km | 2h 30m | 4Z |
| Victoria Falls | VFA | Zimbabwe | 1,900 km | 2h 55m | 4Z, KQ |
| Livingstone | LVI | Zambia | 1,928 km | 2h 50m | KQ, P0 |
| Harare | HRE | Zimbabwe | 2,170 km | 3h 10m | 4Z |
| Luanda | NBJ | Angola | 2,808 km | 4h 5m | DT |
| Dar Es Salaam | DAR | United Republic of Tanzania | 3,673 km | 5h 15m | TC |
| Zanzibar | ZNZ | United Republic of Tanzania | 3,736 km | 5h 15m | 4Z |
| Nairobi | NBO | Kenya | 4,087 km | 5h 45m | KQ |
| Mauritius | MRU | Mauritius | 4,121 km | 5h 5m | 4Z, MK, SA |
| Addis Ababa | ADD | Ethiopia | 5,210 km | 6h 25m | ET |
| Sao Paulo | GRU | Brazil | 6,362 km | 8h 55m | LA, SA |
| Doha | DOH | Qatar | 7,426 km | 9h 35m | QR |
| Dubai | DXB | United Arab Emirates | 7,620 km | 9h 25m | EK |
| Istanbul | IST | Turkiye | 8,394 km | 11h 0m | TK |
| Zurich | ZRH | Switzerland | 9,073 km | 11h 5m | WK |
| Munich | MUC | Germany | 9,143 km | 11h 15m | LH |
| Paris | CDG | France | 9,326 km | 11h 50m | AF |
| Frankfurt | FRA | Germany | 9,358 km | 12h 10m | DE, LH |
| London | LGW | United Kingdom | 9,607 km | 11h 45m | |
| London | LHR | United Kingdom | 9,646 km | 12h 0m | BA, VS |
| Amsterdam | AMS | Netherlands | 9,652 km | 11h 30m | KL |
| New York | EWR | USA | 12,580 km | 15h 45m | UA |
| Dulles | IAD | USA | 12,752 km | 15h 55m | UA |
| Atlanta | ATL | USA | 13,084 km | 16h 15m | DL |