Seychelles International offers nonstop service to 16 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Praslin Island | PRI | Seychelles | 43 km | 0h 20m | HM |
| Mauritius | MRU | Mauritius | 1,759 km | 2h 45m | HM, WK, 4Y |
| Antananarivo | TNR | Madagascar | 1,790 km | 2h 40m | EK |
| Nairobi | NBO | Kenya | 2,098 km | 3h 10m | KQ |
| Addis Ababa | ADD | Ethiopia | 2,391 km | 3h 50m | ET |
| Colombo | CMB | Sri Lanka | 3,008 km | 4h 15m | HM |
| Abu Dhabi | AUH | United Arab Emirates | 3,220 km | 4h 35m | EY, HM |
| Mumbai | BOM | India | 3,244 km | 4h 35m | 6E |
| Dubai | DXB | United Arab Emirates | 3,311 km | 4h 30m | EK |
| Doha | DOH | Qatar | 3,338 km | 4h 45m | QR |
| Johannesburg | JNB | South Africa | 3,751 km | 5h 5m | HM |
| Tel Aviv-Yafo | TLV | Israel | 4,610 km | 6h 20m | HM, IZ |
| Istanbul | IST | Turkiye | 5,768 km | 8h 10m | TK |
| Moscow | SVO | Russia | 6,922 km | 9h 25m | SU |
| Zurich | ZRH | Switzerland | 7,372 km | 9h 45m | WK |
| Frankfurt | FRA | Germany | 7,548 km | 10h 20m | DE, 4Y |