Sir Seewoosagur Ramgoolam International offers nonstop service to 52 destinations, served by 23 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Saint Denis de la Reunion | RUN | Reunion | 231 km | 0h 50m | MK, SS, UU |
| Rodrigues Island | RRG | Mauritius | 599 km | 1h 35m | MK |
| Antananarivo | TNR | Madagascar | 1,085 km | 1h 55m | MK, TK |
| Mahe Island | SEZ | Seychelles | 1,759 km | 2h 45m | 4Y, HM, WK |
| Johannesburg | JNB | South Africa | 3,069 km | 4h 35m | FA, MK, SA |
| Nairobi | NBO | Kenya | 3,092 km | 4h 15m | KQ |
| Addis Ababa | ADD | Ethiopia | 3,854 km | 5h 0m | ET |
| Cape Town | CPT | South Africa | 4,121 km | 6h 0m | 4Z, MK, SA |
| Bengaluru | BLR | India | 4,318 km | 6h 5m | 6E |
| Chennai | MAA | India | 4,440 km | 5h 50m | MK |
| Mumbai | BOM | India | 4,675 km | 6h 20m | AI, MK |
| Dubai | DXB | United Arab Emirates | 5,060 km | 6h 35m | EK |
| Jeddah | JED | Saudi Arabia | 5,074 km | 7h 10m | SV |
| Kuala Lumpur | KUL | Malaysia | 5,446 km | 7h 20m | MK |
| Delhi | DEL | India | 5,808 km | 7h 45m | MK |
| Perth | PER | Australia | 5,894 km | 6h 50m | MK |
| Istanbul | IST | Turkiye | 7,454 km | 9h 30m | TK |
| Rome | FCO | Italy | 8,326 km | 11h 20m | AZ |
| Vienna | VIE | Austria | 8,626 km | 10h 50m | OS |
| Zurich | ZRH | Switzerland | 8,977 km | 11h 30m | WK |
| Geneva | GVA | Switzerland | 9,022 km | 11h 48m | MK |
| Frankfurt | FRA | Germany | 9,178 km | 12h 5m | 4Y, DE |
| Madrid | MAD | Spain | 9,249 km | 11h 55m | 2W, E9 |
| Paris | ORY | France | 9,417 km | 12h 0m | SS |
| Paris | CDG | France | 9,425 km | 12h 5m | AF, MK |
| London | LGW | United Kingdom | 9,727 km | 12h 30m | BA, MK |