Zanzibar offers nonstop service to 28 destinations, served by 28 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dar Es Salaam | DAR | United Republic of Tanzania | 72 km | 0h 20m | CQ, FZ, PW, TC, UI, WY, KL, W2 |
| Pemba | PMA | United Republic of Tanzania | 124 km | 0h 30m | CQ, UI, W2, TC |
| Tanga | TGT | United Republic of Tanzania | 125 km | 0h 30m | CQ, UI, W2 |
| Mombasa | MBA | Kenya | 245 km | 0h 50m | NO, 4Y, DE, F2, W2, JM, OR, WB |
| Kilimanjaro | JRO | United Republic of Tanzania | 390 km | 1h 5m | ET, TK, CQ, TC, PW, AF, UR |
| Arusha | ARK | United Republic of Tanzania | 422 km | 1h 5m | PW, CQ, UI, TC, 8N, W2 |
| Nairobi | NBO | Kenya | 598 km | 1h 20m | KQ, PW, TC |
| Entebbe | EBB | Uganda | 1,023 km | 1h 50m | UR |
| Kigali | KGL | Rwanda | 1,113 km | 2h 30m | WB |
| Addis Ababa | ADD | Ethiopia | 1,681 km | 2h 40m | ET |
| Johannesburg | JNB | South Africa | 2,494 km | 3h 50m | FA, 4Z |
| Doha | DOH | Qatar | 3,732 km | 5h 50m | QR |
| Hurghada | HRG | Egypt | 3,741 km | 5h 0m | SM |
| Abu Dhabi | AUH | United Arab Emirates | 3,780 km | 5h 40m | EY |
| Muscat | MCT | Oman | 3,895 km | 5h 25m | WY |
| Dubai | DXB | United Arab Emirates | 3,896 km | 5h 30m | FZ |
| Cairo | CAI | Egypt | 4,106 km | 2h 0m | SM |
| Istanbul | IST | Turkiye | 5,364 km | 7h 53m | TK |
| Catania | CTA | Italy | 5,448 km | 6h 50m | NO |
| Bari | BRI | Italy | 5,722 km | 7h 35m | NO |
| Rome | FCO | Italy | 5,982 km | 7h 45m | NO |
| Verona | VRN | Italy | 6,374 km | 7h 50m | NO |
| Milan | MXP | Italy | 6,494 km | 8h 40m | NO |
| Zurich | ZRH | Switzerland | 6,664 km | 8h 43m | WK |
| Prague | PRG | Czech Republic | 6,688 km | 8h 30m | NO |
| Madrid | MAD | Spain | 6,772 km | 8h 40m | 2W |
| Frankfurt | FRA | Germany | 6,899 km | 9h 5m | 4Y |
| Paris | CDG | France | 7,077 km | 9h 40m | AF |