Zanzibar offers nonstop service to 63 destinations, served by 27 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Dar Es Salaam | DAR | United Republic of Tanzania | 72 km | 0h 20m | CQ, FZ, KL, PW, TC, UI, WY |
| Pemba | PMA | United Republic of Tanzania | 124 km | 0h 30m | CQ, TC, UI |
| Tanga | TGT | United Republic of Tanzania | 125 km | 0h 30m | CQ, UI |
| Mombasa | MBA | Kenya | 245 km | 0h 55m | 4Y, DE, F2, NO, OR, WB |
| Kilimanjaro | JRO | United Republic of Tanzania | 390 km | 1h 3m | CQ, PW, TC, TK, UR |
| Arusha | ARK | United Republic of Tanzania | 422 km | 1h 15m | 8N, CQ, PW, TC, UI |
| Nairobi | NBO | Kenya | 598 km | 1h 20m | KQ, PW, TC |
| Seronera | SEU | United Republic of Tanzania | 641 km | 2h 30m | |
| Entebbe | EBB | Uganda | 1,023 km | 1h 50m | UR |
| Kigali | KGL | Rwanda | 1,113 km | 2h 30m | WB |
| Addis Ababa | ADD | Ethiopia | 1,681 km | 2h 35m | ET |
| Johannesburg | JNB | South Africa | 2,494 km | 3h 55m | 4Z, FA |
| Doha | DOH | Qatar | 3,732 km | 5h 43m | QR |
| Cape Town | CPT | South Africa | 3,736 km | 5h 30m | 4Z |
| Hurghada | HRG | Egypt | 3,741 km | 5h 20m | SM |
| Abu Dhabi | AUH | United Arab Emirates | 3,780 km | 5h 40m | EY |
| Muscat | MCT | Oman | 3,895 km | 5h 20m | WY |
| Dubai | DXB | United Arab Emirates | 3,896 km | 5h 35m | FZ |
| Cairo | CAI | Egypt | 4,106 km | 6h 5m | MS |
| Istanbul | IST | Turkiye | 5,364 km | 7h 35m | TK |
| Catania | CTA | Italy | 5,448 km | 7h 10m | NO |
| Bari | BRI | Italy | 5,722 km | 7h 35m | NO |
| Rome | FCO | Italy | 5,982 km | 8h 10m | NO |
| Verona | VRN | Italy | 6,374 km | 8h 15m | NO |
| Milan | MXP | Italy | 6,494 km | 8h 25m | NO |
| Zurich | ZRH | Switzerland | 6,664 km | 8h 35m | WK |
| Madrid | MAD | Spain | 6,772 km | 8h 40m | 2W |
| Moscow | VKO | Russia | 6,854 km | 10h 30m | TC |
| Frankfurt | FRA | Germany | 6,899 km | 9h 5m | 4Y |
| Paris | CDG | France | 7,077 km | 9h 45m | AF |