Kotoka International offers nonstop service to 71 destinations, served by 29 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lome | LFW | Togo | 169 km | 0h 50m | KP, SN |
| Takoradi | TKD | Ghana | 194 km | 0h 40m | AW, OP |
| Kumasi | KMS | Ghana | 199 km | 0h 40m | AW, OP |
| Cotonou | COO | Benin | 294 km | 1h 5m | HF, SN |
| Lagos | LOS | Nigeria | 401 km | 1h 5m | AW, P4, QI, UN, UR, VK, WB |
| Abidjan | ABJ | Cote d'Ivoire | 418 km | 1h 0m | 2J, AW, EK, HF, ME, QR, SA |
| Tamale | TML | Ghana | 427 km | 1h 0m | AW |
| Wa | WZA | Ghana | 558 km | 1h 40m | OP |
| Ouagadougou | OUA | Burkina Faso | 760 km | 1h 30m | 2J, AW |
| Abuja | ABV | Nigeria | 903 km | 1h 45m | AW, UN |
| Uyo | QUO | Nigeria | 918 km | 1h 50m | QI |
| Sao Tome Island | TMS | Sao Tome and Principe | 960 km | 1h 48m | TP |
| Monrovia | ROB | Liberia | 1,130 km | 2h 0m | HF, KP, KQ, P4 |
| Freetown | FNA | Sierra Leone | 1,476 km | 2h 50m | KP, KQ, P4 |
| Banjul | BJL | Gambia | 2,000 km | 3h 0m | VK |
| Casablanca | CMN | Morocco | 3,167 km | 4h 25m | AT |
| Kigali | KGL | Rwanda | 3,471 km | 6h 0m | WB |
| Lisbon | LIS | Portugal | 3,782 km | 6h 5m | TP |
| Rome | FCO | Italy | 4,193 km | 5h 45m | AZ |
| Nairobi | NBO | Kenya | 4,194 km | 5h 40m | KQ |
| Cairo | CAI | Egypt | 4,279 km | 5h 45m | MS |
| Addis Ababa | ADD | Ethiopia | 4,317 km | 5h 40m | ET |
| Dar Es Salaam | DAR | United Republic of Tanzania | 4,586 km | 6h 0m | TC |
| Johannesburg | JNB | South Africa | 4,663 km | 5h 55m | SA |
| Beirut | BEY | Lebanon | 4,825 km | 6h 15m | ME |
| Istanbul | IST | Turkiye | 4,883 km | 6h 55m | TK |
| Brussels | BRU | Belgium | 5,039 km | 6h 40m | SN |
| London | LGW | United Kingdom | 5,048 km | 6h 45m | BA |
| London | LHR | United Kingdom | 5,084 km | 7h 5m | BA |
| Amsterdam | AMS | Netherlands | 5,197 km | 6h 45m | KL |
| Doha | DOH | Qatar | 5,923 km | 7h 20m | QR |
| Abu Dhabi | AUH | United Arab Emirates | 6,205 km | 8h 10m | EY |
| Dubai | DXB | United Arab Emirates | 6,293 km | 7h 50m | EK |
| New York | JFK | USA | 8,225 km | 11h 11m | DL |
| Dulles | IAD | USA | 8,521 km | 11h 35m | UA |
| Atlanta | ATL | USA | 9,140 km | 12h 38m | DL |