Lusaka International offers nonstop service to 45 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Lower Zambezi National Park | RYL | Zambia | 101 km | 0h 35m | P0 |
| Jeki | JEK | Zambia | 128 km | 0h 35m | P0 |
| Ndola | NLA | Zambia | 261 km | 0h 45m | P0, ZN |
| Livingstone | LVI | Zambia | 393 km | 1h 10m | P0, ZN |
| Harare | HRE | Zimbabwe | 403 km | 1h 0m | BP, EK, ET, KQ, QR, RN, UR, WB, ZN |
| Solwezi | SLI | Zambia | 415 km | 0h 55m | P0 |
| Lubumbashi | FBM | The Democratic Republic of The Congo | 425 km | 1h 5m | TC |
| Mfuwe | MFU | Zambia | 439 km | 1h 10m | P0 |
| Mansa | MNS | Zambia | 467 km | 1h 15m | P0 |
| Kalumbila | UMB | Zambia | 470 km | 1h 15m | P0 |
| Lilongwe | LLW | Malawi | 599 km | 1h 10m | ET |
| Kasama | KAA | Zambia | 636 km | 1h 35m | P0 |
| Gaborone | GBE | Botswana | 1,055 km | 1h 40m | BP |
| Johannesburg | JNB | South Africa | 1,197 km | 2h 0m | 4Z, FA, P0, SA, WB, ZN |
| Manzini | SHO | Eswatini | 1,267 km | 2h 0m | RN |
| Windhoek | WDH | Namibia | 1,401 km | 2h 5m | P0 |
| Kigali | KGL | Rwanda | 1,489 km | 2h 35m | WB |
| Dar Es Salaam | DAR | United Republic of Tanzania | 1,500 km | 2h 30m | TC, ZN |
| Entebbe | EBB | Uganda | 1,756 km | 2h 45m | UR |
| Nairobi | NBO | Kenya | 1,807 km | 2h 50m | KQ, ZN |
| Addis Ababa | ADD | Ethiopia | 2,920 km | 4h 0m | ET |
| Doha | DOH | Qatar | 5,145 km | 7h 0m | QR |
| Dubai | DXB | United Arab Emirates | 5,355 km | 6h 55m | EK |