Antigua offers nonstop service to 28 destinations, served by 19 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Montserrat | MNI | Montserrat | 57 km | 0h 20m | 5M, WM |
| Saint Kitts | SKB | St. Kitts and Nevis | 99 km | 0h 50m | BA, BW, S6, 5L, Z6 |
| Pointe-a-Pitre | PTP | Guadeloupe | 100 km | 0h 30m | S6 |
| Saint Barthelemy | SBH | Saint Barthelemy | 140 km | 0h 36m | TJ |
| Sint Maarten | SXM | Sint Maarten | 171 km | 0h 50m | WM, S6, 5L |
| Anguilla | AXA | Anguilla | 178 km | 0h 45m | Q3 |
| Dominica | DOM | Dominica | 183 km | 0h 45m | WM, S6, 5L, Z6 |
| Beef Island | EIS | British Virgin Islands | 324 km | 1h 0m | JY, WM, S6, 5L |
| Saint Lucia | SLU | Saint Lucia | 355 km | 0h 50m | 5L |
| Saint Lucia | UVF | Saint Lucia | 387 km | 1h 10m | S6 |
| Saint Vincent | SVD | Saint Vincent and the Grenadines | 446 km | 1h 15m | 5L, S6 |
| Bridgetown | BGI | Barbados | 512 km | 1h 5m | BW, JY, VS, 5L, S6 |
| St. George's | GND | Grenada | 568 km | 1h 25m | 5L |
| Punta Cana | PUJ | Dominican Republic | 714 km | 1h 25m | DE |
| Port Of Spain | POS | Trinidad and Tobago | 724 km | 1h 40m | BW, 5L |
| Santo Domingo | SDQ | Dominican Republic | 848 km | 2h 0m | DO, 5L |
| Georgetown | OGL | Guyana | 1,211 km | 3h 10m | 5L |
| Providenciales | PLS | Turks and Caicos Islands | 1,212 km | 2h 0m | JY |
| Georgetown | GEO | Guyana | 1,237 km | 2h 10m | 5L |
| Kingston | KIN | Jamaica | 1,594 km | 2h 40m | BW, 5L |
| Miami | MIA | USA | 2,138 km | 3h 42m | AA |
| Charlotte | CLT | USA | 2,759 km | 4h 54m | AA |
| New York | JFK | USA | 2,849 km | 4h 45m | AA, B6, DL |
| New York | EWR | USA | 2,869 km | 4h 57m | UA |
| Atlanta | ATL | USA | 2,909 km | 4h 45m | DL |
| Toronto | YYZ | Canada | 3,387 km | 5h 20m | AC, WS |
| London | LHR | United Kingdom | 6,557 km | 8h 15m | VS |
| London | LGW | United Kingdom | 6,569 km | 8h 0m | BA |