Hugo Chavez International Airport offers nonstop service to 10 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Port-au-Prince | PAP | Haiti | 128 km | 0h 30m | S6 |
| Providenciales | PLS | Turks and Caicos Islands | 226 km | 0h 45m | 9Q, JY, S6 |
| Les Cayes | CYA | Haiti | 233 km | 0h 50m | S6 |
| Nassau | NAS | Bahamas | 800 km | 2h 5m | UP |
| Sint Maarten | SXM | Sint Maarten | 975 km | 2h 0m | S6 |
| Miami | MIA | USA | 1,067 km | 2h 0m | S6 |
| Fort Lauderdale | FLL | USA | 1,075 km | 2h 0m | S6 |
| Pointe-a-Pitre | PTP | Guadeloupe | 1,192 km | 2h 0m | S6 |
| New York | EWR | USA | 2,330 km | 4h 30m | S6 |
| Boston | BOS | USA | 2,511 km | 4h 30m | S6 |