Saint Thomas offers nonstop service to 54 destinations, served by 11 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Beef Island | EIS | British Virgin Islands | 47 km | 0h 22m | 9K |
| Ceiba | NRR | Puerto Rico | 71 km | 0h 30m | VD |
| Saint Croix | STX | U.S. Virgin Islands | 72 km | 0h 25m | 9K |
| San Juan | SJU | Puerto Rico | 109 km | 0h 44m | 9K, B6, SY |
| Sint Maarten | SXM | Sint Maarten | 199 km | 0h 55m | LF |
| Anguilla | AXA | Anguilla | 203 km | 0h 55m | 9K |
| Saint Barthelemy | SBH | Saint Barthelemy | 230 km | 1h 20m | 9K |
| Saint Kitts | SKB | St. Kitts and Nevis | 264 km | 1h 10m | 9K |
| Nevis | NEV | St. Kitts and Nevis | 281 km | 1h 14m | 9K |
| Santo Domingo | SDQ | Dominican Republic | 497 km | 1h 5m | DO |
| Dominica | DOM | Dominica | 498 km | 1h 30m | LF |
| Miami | MIA | USA | 1,780 km | 3h 10m | AA |
| Orlando | MCO | USA | 2,006 km | 3h 30m | WN |
| Tampa | TPA | USA | 2,088 km | 4h 30m | MX |
| Charlotte | CLT | USA | 2,446 km | 4h 9m | AA |
| Baltimore | BWI | USA | 2,571 km | 4h 25m | WN |
| Atlanta | ATL | USA | 2,575 km | 4h 11m | DL |
| Philadelphia | PHL | USA | 2,583 km | 4h 20m | AA |
| Dulles | IAD | USA | 2,584 km | 4h 23m | UA |
| New York | JFK | USA | 2,612 km | 4h 27m | AA, DL |
| New York | EWR | USA | 2,629 km | 4h 33m | UA |
| Boston | BOS | USA | 2,724 km | 4h 20m | DL |
| Nashville | BNA | USA | 2,903 km | 4h 33m | WN |
| Houston | IAH | USA | 3,331 km | 5h 22m | UA |
| Chicago | ORD | USA | 3,404 km | 5h 43m | AA, UA |
| Dallas | DFW | USA | 3,581 km | 5h 47m | AA |
| Minneapolis | MSP | USA | 3,940 km | 6h 17m | SY |