Louis Armstrong New Orleans International offers nonstop service to 58 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Houston | HOU | USA | 486 km | 1h 20m | WN |
| Houston | IAH | USA | 490 km | 1h 23m | UA, F9 |
| Memphis | MEM | USA | 561 km | 1h 20m | AA |
| Atlanta | ATL | USA | 683 km | 1h 31m | DL, WN, F9 |
| Dallas | DAL | USA | 702 km | 1h 30m | WN |
| Austin | AUS | USA | 714 km | 1h 30m | WN, DL |
| Dallas | DFW | USA | 720 km | 1h 50m | AA, NK, F9 |
| Nashville | BNA | USA | 759 km | 1h 35m | WN |
| Tampa | TPA | USA | 784 km | 1h 35m | NK, WN, MX |
| Bentonville | XNA | USA | 792 km | 1h 46m | MX |
| San Antonio | SAT | USA | 796 km | 1h 40m | WN |
| Jacksonville | JAX | USA | 826 km | 1h 34m | MX |
| Knoxville | TYS | USA | 871 km | 2h 0m | AA |
| Punta Gorda | PGD | USA | 877 km | 1h 53m | G4 |
| Orlando | MCO | USA | 886 km | 1h 48m | F9, NK, WN, MX |
| Savannah | SAV | USA | 895 km | 1h 36m | MX |
| Fort Myers | RSW | USA | 917 km | 1h 46m | MX |
| Greenville | GSP | USA | 930 km | 1h 45m | WN |
| Saint Louis | STL | USA | 972 km | 1h 50m | WN |
| Louisville | SDF | USA | 999 km | 1h 54m | MX, AA |
| Charleston | CHS | USA | 1,022 km | 1h 48m | MX |
| Lexington | LEX | USA | 1,034 km | 2h 0m | AA |
| Cancun | CUN | Mexico | 1,047 km | 1h 55m | WN, NK, MX |
| Charlotte | CLT | USA | 1,049 km | 2h 6m | AA |
| Fort Lauderdale | FLL | USA | 1,084 km | 1h 50m | B6, NK, WN |
| Miami | MIA | USA | 1,085 km | 2h 1m | AA, NK |
| Kansas City | MCI | USA | 1,110 km | 2h 0m | WN |
| Cincinnati | CVG | USA | 1,129 km | 2h 4m | G4 |
| Myrtle Beach | MYR | USA | 1,147 km | 2h 5m | MX |
| Raleigh/Durham | RDU | USA | 1,254 km | 2h 5m | WN, MX |
| Wilmington | ILM | USA | 1,256 km | 2h 5m | MX |
| Chicago | MDW | USA | 1,329 km | 2h 20m | WN |
| Chicago | ORD | USA | 1,347 km | 2h 41m | AA, NK, UA |
| Richmond | RIC | USA | 1,457 km | 2h 15m | MX |
| Pittsburgh | PIT | USA | 1,477 km | 2h 23m | MX |
| Detroit | DTW | USA | 1,490 km | 2h 32m | DL, F9 |
| Norfolk | ORF | USA | 1,512 km | 2h 17m | MX |
| Dulles | IAD | USA | 1,538 km | 2h 32m | UA |
| Washington | DCA | USA | 1,560 km | 2h 34m | AA, WN |
| Baltimore | BWI | USA | 1,607 km | 2h 30m | WN, F9 |
| San Pedro Sula | SAP | Honduras | 1,626 km | 2h 28m | NK |
| Minneapolis | MSP | USA | 1,673 km | 2h 47m | DL, SY |
| Denver | DEN | USA | 1,708 km | 2h 59m | F9, UA, WN |
| Philadelphia | PHL | USA | 1,752 km | 2h 53m | AA, F9 |
| Toronto | YYZ | Canada | 1,788 km | 2h 52m | AC |
| New York | EWR | USA | 1,877 km | 3h 3m | UA |
| New York | JFK | USA | 1,902 km | 3h 1m | B6, DL |
| New York | LGA | USA | 1,904 km | 2h 55m | DL, WN, AA |
| Phoenix | PHX | USA | 2,092 km | 3h 30m | WN, AA |
| Boston | BOS | USA | 2,200 km | 3h 20m | B6, DL |
| Salt Lake City | SLC | USA | 2,299 km | 3h 46m | DL |
| Las Vegas | LAS | USA | 2,413 km | 3h 50m | WN, F9, MX |
| San Diego | SAN | USA | 2,574 km | 4h 5m | WN |
| Los Angeles | LAX | USA | 2,688 km | 4h 20m | DL, WN, MX |
| San Francisco | SFO | USA | 3,076 km | 4h 52m | UA |
| Portland | PDX | USA | 3,299 km | 5h 9m | AS |
| Seattle | SEA | USA | 3,356 km | 5h 19m | AS |
| London | LHR | United Kingdom | 7,451 km | 8h 50m | BA |