San Antonio International offers nonstop service to 47 destinations, served by 13 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Houston | IAH | USA | 307 km | 1h 7m | UA |
| Houston | HOU | USA | 309 km | 1h 0m | WN |
| Dallas | DFW | USA | 398 km | 1h 19m | AA |
| Dallas | DAL | USA | 399 km | 1h 10m | WN |
| Monterrey | MTY | Mexico | 445 km | 1h 10m | VB |
| New Orleans | MSY | USA | 796 km | 1h 25m | WN |
| El Paso | ELP | USA | 799 km | 1h 30m | WN |
| San Luis Potosi | SLP | Mexico | 842 km | 1h 29m | Y4 |
| Albuquerque | ABQ | USA | 981 km | 1h 50m | WN |
| Leon/Guanajuato | BJX | Mexico | 992 km | 1h 41m | VB |
| Queretaro | QRO | Mexico | 1,001 km | 1h 50m | VB, Y4 |
| Memphis | MEM | USA | 1,006 km | 1h 55m | MX |
| Pensacola | PNS | USA | 1,092 km | 2h 0m | MX |
| Morelia | MLM | Mexico | 1,103 km | 2h 3m | Y4 |
| Guadalajara | GDL | Mexico | 1,110 km | 2h 1m | Y4 |
| Mexico City | MEX | Mexico | 1,119 km | 2h 15m | AM, Y4, VB |
| Kansas City | MCI | USA | 1,136 km | 1h 55m | WN |
| Saint Louis | STL | USA | 1,265 km | 2h 10m | WN |
| Denver | DEN | USA | 1,277 km | 2h 16m | F9, UA, WN |
| Nashville | BNA | USA | 1,324 km | 2h 10m | WN |
| Phoenix | PHX | USA | 1,355 km | 2h 30m | AA, F9, WN |
| Atlanta | ATL | USA | 1,406 km | 2h 22m | DL, F9, WN |
| Cancun | CUN | Mexico | 1,497 km | 2h 30m | WN, SY |
| Tampa | TPA | USA | 1,564 km | 2h 20m | WN |
| Chicago | MDW | USA | 1,669 km | 2h 35m | WN |
| Orlando | MCO | USA | 1,675 km | 2h 35m | F9, WN, NK |
| Chicago | ORD | USA | 1,677 km | 2h 57m | AA, UA |
| Las Vegas | LAS | USA | 1,719 km | 2h 50m | F9, WN |
| Salt Lake City | SLC | USA | 1,749 km | 2h 59m | DL |
| Charlotte | CLT | USA | 1,763 km | 2h 51m | AA |
| Minneapolis | MSP | USA | 1,766 km | 2h 51m | DL, SY |
| San Diego | SAN | USA | 1,818 km | 2h 53m | WN |
| Miami | MIA | USA | 1,839 km | 2h 51m | AA |
| Fort Lauderdale | FLL | USA | 1,844 km | 2h 39m | NK |
| Los Angeles | LAX | USA | 1,948 km | 3h 21m | AA, DL, WN |
| Detroit | DTW | USA | 1,954 km | 3h 8m | DL |
| Raleigh/Durham | RDU | USA | 1,970 km | 2h 55m | MX |
| Dulles | IAD | USA | 2,193 km | 3h 21m | UA |
| Washington | DCA | USA | 2,222 km | 3h 17m | AA |
| Baltimore | BWI | USA | 2,265 km | 3h 20m | WN |
| Toronto | YYZ | Canada | 2,295 km | 3h 30m | AC |
| San Francisco | SFO | USA | 2,386 km | 4h 13m | UA |
| Philadelphia | PHL | USA | 2,407 km | 3h 41m | AA |
| New York | EWR | USA | 2,525 km | 3h 52m | UA |
| New York | JFK | USA | 2,554 km | 3h 59m | DL |
| Boston | BOS | USA | 2,838 km | 4h 11m | DL |
| Seattle | SEA | USA | 2,855 km | 4h 34m | AS |