Panama City-NW Florida Bea. offers nonstop service to 40 destinations, served by 4 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Atlanta | ATL | USA | 386 km | 1h 14m | DL |
| Nashville | BNA | USA | 645 km | 1h 30m | WN |
| Charlotte | CLT | USA | 705 km | 1h 48m | AA |
| Houston | HOU | USA | 917 km | 1h 55m | WN |
| Houston | IAH | USA | 919 km | 2h 5m | UA |
| Saint Louis | STL | USA | 1,021 km | 1h 53m | WN |
| Indianapolis | IND | USA | 1,039 km | 1h 55m | WN |
| Dallas | DAL | USA | 1,083 km | 2h 10m | WN |
| Columbus | CMH | USA | 1,102 km | 1h 55m | WN |
| Dallas | DFW | USA | 1,102 km | 2h 26m | AA |
| Austin | AUS | USA | 1,141 km | 2h 15m | DL, WN |
| Washington | DCA | USA | 1,237 km | 2h 17m | AA |
| Chicago | MDW | USA | 1,280 km | 2h 20m | WN |
| Kansas City | MCI | USA | 1,282 km | 2h 20m | WN |
| Baltimore | BWI | USA | 1,285 km | 2h 13m | WN |
| Chicago | ORD | USA | 1,303 km | 2h 44m | AA, UA |
| Milwaukee | MKE | USA | 1,409 km | 2h 45m | WN |
| Philadelphia | PHL | USA | 1,426 km | 2h 34m | AA |
| New York | LGA | USA | 1,579 km | 2h 43m | DL |
| Denver | DEN | USA | 2,011 km | 3h 25m | UA, WN |