Pensacola Rgnl offers nonstop service to 49 destinations, served by 6 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Atlanta | ATL | USA | 436 km | 1h 16m | DL |
| Tampa | TPA | USA | 530 km | 1h 23m | MX |
| Memphis | MEM | USA | 569 km | 1h 29m | MX |
| Orlando | MCO | USA | 614 km | 1h 30m | F9, MX, WN |
| Nashville | BNA | USA | 629 km | 1h 30m | WN |
| Houston | HOU | USA | 784 km | 1h 45m | WN |
| Houston | IAH | USA | 785 km | 1h 54m | UA |
| Charlotte | CLT | USA | 787 km | 1h 52m | AA |
| Fort Lauderdale | FLL | USA | 846 km | 1h 45m | MX |
| Miami | MIA | USA | 854 km | 1h 47m | AA |
| Bentonville | XNA | USA | 921 km | 1h 52m | MX |
| Dallas | DAL | USA | 952 km | 1h 55m | WN |
| Saint Louis | STL | USA | 962 km | 1h 50m | WN |
| Dallas | DFW | USA | 970 km | 2h 15m | AA |
| Raleigh/Durham | RDU | USA | 985 km | 1h 48m | MX |
| Austin | AUS | USA | 1,007 km | 1h 55m | WN |
| San Antonio | SAT | USA | 1,092 km | 1h 59m | MX |
| Kansas City | MCI | USA | 1,194 km | 2h 10m | WN |
| Chicago | MDW | USA | 1,256 km | 2h 20m | WN |
| Chicago | ORD | USA | 1,277 km | 2h 46m | AA, UA |
| Washington | DCA | USA | 1,313 km | 2h 24m | AA |
| Philadelphia | PHL | USA | 1,504 km | 2h 37m | AA |
| New York | LGA | USA | 1,658 km | 2h 41m | AA, DL |
| Denver | DEN | USA | 1,896 km | 3h 15m | F9, UA, WN |