Nantes Airport offers nonstop service to 192 destinations, served by 22 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Saint Nazaire | SNR | France | 45 km | 0h 25m | XK |
| Paris | ORY | France | 343 km | 1h 15m | SS, TO |
| Paris | CDG | France | 372 km | 1h 10m | AF |
| Toulouse | TLS | France | 455 km | 1h 10m | U2, V7 |
| London | LGW | United Kingdom | 456 km | 1h 20m | U2 |
| Lyon | LYS | France | 537 km | 1h 15m | AF, U2, V7 |
| London | STN | United Kingdom | 543 km | 1h 25m | FR, RK |
| Brussels | CRL | Belgium | 576 km | 1h 25m | V7 |
| Montpellier | MPL | France | 589 km | 1h 20m | V7 |
| Geneva | GVA | Switzerland | 598 km | 1h 20m | U2 |
| Perpignan | PGF | France | 604 km | 1h 20m | V7 |
| Brussels | BRU | Belgium | 608 km | 1h 25m | U2 |
| Marseille | MRS | France | 675 km | 1h 30m | FR, TO |
| Basel, Switzerland/Mulhouse | BSL | France | 691 km | 1h 30m | U2 |
| Manchester | MAN | United Kingdom | 691 km | 1h 35m | FR |
| Strasbourg | SXB | France | 707 km | 1h 30m | V7 |
| Barcelona | BCN | Spain | 713 km | 1h 30m | V7, VY |
| Amsterdam | AMS | Netherlands | 733 km | 1h 35m | KL |
| Madrid | MAD | Spain | 757 km | 1h 45m | IB, U2, V7 |
| Dublin | DUB | Ireland | 771 km | 1h 40m | EI, FR |
| Nice | NCE | France | 790 km | 1h 35m | U2, V7 |
| Milan | MXP | Italy | 810 km | 1h 40m | U2 |
| Frankfurt | FRA | Germany | 815 km | 1h 35m | LH |
| Valencia | VLC | Spain | 856 km | 1h 40m | FR |
| Porto | OPO | Portugal | 866 km | 1h 45m | TO, U2, V7 |
| Milan | BGY | Italy | 883 km | 1h 50m | V7 |
| Palma de Mallorca | PMI | Spain | 915 km | 1h 45m | TO, U2, V7, VY |
| Menorca | MAH | Spain | 936 km | 1h 45m | U2, V7 |
| Ibiza | IBZ | Spain | 951 km | 1h 50m | U2 |
| Calvi | CLY | France | 968 km | 1h 40m | V7 |
| Edinburgh | EDI | United Kingdom | 985 km | 1h 50m | FR |
| Alicante | ALC | Spain | 989 km | 1h 55m | U2, V7 |
| Ajaccio | AJA | France | 1,009 km | 1h 45m | TO, U2, V7 |
| Munich | MUC | Germany | 1,011 km | 2h 0m | LH |
| Bastia | BIA | France | 1,013 km | 1h 50m | TO, V7 |
| Pisa | PSA | Italy | 1,013 km | 1h 50m | V7 |
| Figari | FSC | France | 1,058 km | 1h 50m | TO, V7 |
| Florence | FLR | Italy | 1,066 km | 1h 50m | V7 |
| Venice | VCE | Italy | 1,087 km | 2h 0m | V7 |
| Lisbon | LIS | Portugal | 1,114 km | 2h 5m | TO, U2, V7 |
| Granada | GRX | Spain | 1,122 km | 2h 5m | V7 |
| Olbia | OLB | Italy | 1,128 km | 2h 0m | U2, V7 |
| Sevilla | SVQ | Spain | 1,137 km | 2h 0m | FR, TO |
| Malaga | AGP | Spain | 1,188 km | 2h 5m | U2, V7 |
| Prague | PRG | Czech Republic | 1,212 km | 2h 5m | U2, V7 |
| Algiers | ALG | Algeria | 1,227 km | 2h 10m | AH, TO |
| Berlin | BER | Germany | 1,229 km | 2h 10m | TO |
| Faro | FAO | Portugal | 1,242 km | 2h 10m | TO, U2, V7 |
| Rome | FCO | Italy | 1,250 km | 2h 15m | U2, V7 |
| Oran | ORN | Algeria | 1,284 km | 2h 20m | TO |
| Tangier | TNG | Morocco | 1,319 km | 2h 55m | TO |
| Copenhagen | CPH | Denmark | 1,363 km | 2h 20m | V7 |
| Vienna | VIE | Austria | 1,365 km | 2h 25m | V7 |
| Naples | NAP | Italy | 1,448 km | 2h 25m | U2, V7 |
| Split | SPU | Croatia | 1,455 km | 2h 20m | OU, V7 |
| Fes | FEZ | Morocco | 1,496 km | 2h 25m | FR |
| Tunis | TUN | Tunisia | 1,503 km | 2h 25m | BJ, TO |
| Rabat | RBA | Morocco | 1,519 km | 2h 30m | U2 |
| Palermo | PMO | Italy | 1,559 km | 2h 30m | TO, V7 |
| Budapest | BUD | Hungary | 1,573 km | 2h 30m | U2 |
| Bari | BRI | Italy | 1,609 km | 2h 35m | TO |
| Casablanca | CMN | Morocco | 1,612 km | 2h 35m | AT, TO |
| Monastir | MIR | Tunisia | 1,629 km | 2h 30m | BJ, TO |
| Dubrovnik | DBV | Croatia | 1,645 km | 2h 30m | U2, V7 |
| Brindisi | BDS | Italy | 1,721 km | 2h 40m | V7 |
| Podgorica | TGD | Montenegro | 1,728 km | 2h 35m | 4O |
| Catania | CTA | Italy | 1,739 km | 2h 45m | U2, V7 |
| Djerba | DJE | Tunisia | 1,805 km | 2h 45m | BJ, TO |
| Marrakech | RAK | Morocco | 1,812 km | 3h 0m | AT, TO, U2, V7 |
| Malta | MLA | Malta | 1,832 km | 2h 50m | FR |
| Essaouira | ESU | Morocco | 1,880 km | 3h 0m | U2 |
| Kerkyra | CFU | Greece | 1,926 km | 2h 55m | U2, V7 |
| Agadir | AGA | Morocco | 1,985 km | 3h 10m | FR, TO, V7 |
| Funchal | FNC | Portugal | 2,056 km | 3h 15m | TO, U2 |
| Patras | GPA | Greece | 2,125 km | 3h 0m | V7 |
| Lanzarote | ACE | Spain | 2,273 km | 3h 35m | TO, U2, V7 |
| Athens | ATH | Greece | 2,320 km | 3h 25m | A3, TO, V7 |
| Puerto del Rosario | FUE | Spain | 2,334 km | 3h 40m | V7 |
| Varna | VAR | Bulgaria | 2,338 km | 3h 23m | V7 |
| Las Palmas | LPA | Spain | 2,448 km | 3h 50m | U2, V7 |
| Tenerife | TFS | Spain | 2,489 km | 3h 50m | TO, U2, V7 |
| Chania | CHQ | Greece | 2,493 km | 3h 35m | U2 |
| Istanbul | IST | Turkiye | 2,494 km | 4h 0m | TO |
| Thira | JTR | Greece | 2,529 km | 3h 40m | TO |
| Heraklion | HER | Greece | 2,580 km | 3h 45m | GQ, TO, U2, V7 |
| Rhodes | RHO | Greece | 2,719 km | 3h 53m | TO, V7 |
| Antalya | AYT | Turkiye | 2,888 km | 4h 15m | TO |
| Cairo | CAI | Egypt | 3,400 km | 4h 40m | TO |
| Hurghada | HRG | Egypt | 3,795 km | 5h 0m | TO, U2 |
| Luxor | LXR | Egypt | 3,840 km | 5h 0m | U2 |
| Dakar | DSS | Senegal | 3,877 km | 5h 35m | TO |
| Boa Vista | BVC | Cape Verde | 3,959 km | 5h 45m | TO |
| Sao Vicente | VXE | Cape Verde | 3,993 km | 5h 45m | TO |
| Quebec | YQB | Canada | 5,123 km | 7h 28m | TS |
| Montreal | YUL | Canada | 5,355 km | 7h 35m | AC, TS |
| Pointe-a-Pitre | PTP | Guadeloupe | 6,434 km | 8h 45m | SS |