Entzheim offers nonstop service to 93 destinations, served by 16 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Frankfurt | FRA | Germany | 180 km | 0h 55m | LH, LO |
| Munich | MUC | Germany | 308 km | 1h 10m | V7 |
| Milan | MXP | Italy | 334 km | 1h 5m | U2 |
| Brussels | BRU | Belgium | 346 km | 0h 55m | A3, RO |
| Lyon | LYS | France | 368 km | 1h 10m | T7 |
| Nice | NCE | France | 543 km | 1h 25m | U2, V7 |
| Florence | FLR | Italy | 594 km | 1h 25m | V7 |
| Marseille | MRS | France | 596 km | 1h 25m | V7 |
| Rodez | RDZ | France | 605 km | 1h 15m | V7 |
| Montpellier | MPL | France | 620 km | 1h 20m | V7 |
| London | LGW | United Kingdom | 631 km | 1h 35m | U2 |
| London | STN | United Kingdom | 643 km | 1h 45m | LS |
| Calvi | CLY | France | 674 km | 1h 15m | V7 |
| London | LTN | United Kingdom | 680 km | 1h 30m | U2 |
| Bastia | BIA | France | 682 km | 1h 25m | V7 |
| Nantes | NTE | France | 707 km | 1h 35m | V7 |
| Toulouse | TLS | France | 729 km | 1h 30m | V7 |
| Ajaccio | AJA | France | 741 km | 1h 30m | V7 |
| Bordeaux | BOD | France | 758 km | 1h 35m | V7 |
| Figari | FSC | France | 791 km | 1h 35m | V7 |
| Bristol | BRS | United Kingdom | 805 km | 1h 45m | U2 |
| Rome | FCO | Italy | 833 km | 1h 40m | U2, V7 |
| Lourdes | LDE | France | 838 km | 1h 40m | V7 |
| Copenhagen | CPH | Denmark | 859 km | 1h 45m | V7 |
| Olbia | OLB | Italy | 862 km | 1h 40m | V7 |
| Manchester | MAN | United Kingdom | 876 km | 1h 45m | LS, U2 |
| Brest | BES | France | 889 km | 1h 45m | V7 |
| Barcelona | BCN | Spain | 915 km | 1h 55m | IB, U2, V7, VY |
| Naples | NAP | Italy | 1,000 km | 1h 48m | U2 |
| Bilbao | BIO | Spain | 1,001 km | 2h 0m | IB |
| Warsaw | WAW | Poland | 1,029 km | 2h 0m | LO |
| Palma de Mallorca | PMI | Spain | 1,073 km | 2h 0m | U2, V7 |
| Edinburgh | EDI | United Kingdom | 1,111 km | 2h 10m | LS |
| Palermo | PMO | Italy | 1,232 km | 2h 10m | V7 |
| Madrid | MAD | Spain | 1,259 km | 2h 20m | IB |
| Tunis | TUN | Tunisia | 1,316 km | 2h 10m | BJ, TU |
| Algiers | ALG | Algeria | 1,364 km | 2h 20m | AH, TO |
| Constantine | CZL | Algeria | 1,364 km | 2h 15m | TO |
| Kerkyra | CFU | Greece | 1,394 km | 2h 15m | V7 |
| Bucharest | OTP | Romania | 1,477 km | 2h 25m | A2, RO |
| Porto | OPO | Portugal | 1,517 km | 2h 30m | V7 |
| Malaga | AGP | Spain | 1,647 km | 2h 45m | V7 |
| Djerba | DJE | Tunisia | 1,650 km | 2h 35m | BJ |
| Athens | ATH | Greece | 1,766 km | 2h 55m | A3, V7 |
| Heraklion | HER | Greece | 2,056 km | 3h 0m | V7 |
| Casablanca | CMN | Morocco | 2,108 km | 3h 15m | AT |
| Marrakech | RAK | Morocco | 2,297 km | 3h 35m | U2, V7 |