Habib Bourguiba International offers nonstop service to 49 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Tunis | TUN | Tunisia | 129 km | 0h 35m | TU |
| Djerba | DJE | Tunisia | 209 km | 0h 40m | NO, TU |
| Nice | NCE | France | 928 km | 1h 45m | BJ, TU |
| Bologna | BLQ | Italy | 974 km | 1h 50m | NO |
| Marseille | MRS | France | 975 km | 1h 50m | BJ, TO, TU |
| Verona | VRN | Italy | 1,070 km | 1h 50m | NO |
| Milan | MXP | Italy | 1,109 km | 1h 50m | NO |
| Lyon | LYS | France | 1,204 km | 2h 5m | BJ, TO, TU |
| Berne | BRN | Switzerland | 1,267 km | 2h 10m | 2L |
| Munich | MUC | Germany | 1,401 km | 2h 20m | 4Y, TU |
| Luxembourg | LUX | Luxembourg | 1,584 km | 2h 30m | LG |
| Paris | ORY | France | 1,595 km | 2h 50m | TO, TU |
| Frankfurt | FRA | Germany | 1,597 km | 2h 40m | 4Y, BJ |
| Paris | CDG | France | 1,615 km | 2h 45m | BJ, TU |
| Nantes | NTE | France | 1,629 km | 2h 40m | BJ, TO |
| Cologne | CGN | Germany | 1,704 km | 2h 40m | EW |
| Dusseldorf | DUS | Germany | 1,753 km | 2h 55m | BJ, EW |
| Brussels | BRU | Belgium | 1,755 km | 2h 50m | BJ, SN |
| Lille | LIL | France | 1,756 km | 2h 50m | BJ |
| Berlin | BER | Germany | 1,857 km | 3h 0m | BJ |
| Hamburg | HAM | Germany | 1,986 km | 3h 5m | TU |
| Moscow | VKO | Russia | 2,986 km | 4h 30m | BJ |
| Saint Petersburg | LED | Russia | 3,020 km | 4h 25m | BJ |
| Jeddah | JED | Saudi Arabia | 3,166 km | 4h 35m | SV |