Blaise Diagne Interantional Airport offers nonstop service to 37 destinations, served by 26 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Banjul | BJL | Gambia | 153 km | 0h 45m | SN, P4, HC, NO |
| Cap Skirring | CSK | Senegal | 254 km | 0h 50m | HC, W2 |
| Bissau | OXB | Guinea-Bissau | 343 km | 1h 0m | KP, TK |
| Nouakchott | NKC | Mauritania | 419 km | 1h 8m | L6, HC |
| Sal | SID | Cape Verde | 669 km | 1h 20m | HC, TB, LG |
| Conakry | CKY | Guinea | 677 km | 1h 20m | SN, TU, L6, HC, W2 |
| Praia | RAI | Cape Verde | 691 km | 2h 0m | HC, KP, W2 |
| Bamako | BKO | Mali | 1,014 km | 1h 50m | ET, HC, 2J |
| Las Palmas | LPA | Spain | 1,478 km | 2h 15m | NT |
| Ouagadougou | OUA | Burkina Faso | 1,703 km | 3h 10m | HC, KP |
| Abidjan | ABJ | Cote d'Ivoire | 1,776 km | 2h 50m | KQ, HF, HC, L6, P4 |
| Niamey | NIM | Niger | 2,082 km | 3h 30m | KP |
| Lome | LFW | Togo | 2,213 km | 3h 30m | KP |
| Casablanca | CMN | Morocco | 2,281 km | 3h 10m | AT, HC |
| Cotonou | COO | Benin | 2,317 km | 3h 30m | HC |
| Lisbon | LIS | Portugal | 2,781 km | 4h 0m | TP |
| Madrid | MAD | Spain | 3,147 km | 4h 25m | IB |
| Algiers | ALG | Algeria | 3,162 km | 4h 20m | AH |
| Tunis | TUN | Tunisia | 3,652 km | 4h 40m | TU |
| Toulouse | TLS | France | 3,658 km | 5h 0m | TO |
| Bordeaux | BOD | France | 3,683 km | 5h 0m | TO |
| Marseille | MRS | France | 3,831 km | 5h 15m | TO |
| Nantes | NTE | France | 3,877 km | 5h 20m | TO |
| Nice | NCE | France | 3,956 km | 5h 15m | TO |
| Lyon | LYS | France | 4,019 km | 5h 25m | TO |
| Rome | FCO | Italy | 4,121 km | 5h 30m | AZ |
| Milan | MXP | Italy | 4,197 km | 5h 30m | NO |
| Paris | CDG | France | 4,208 km | 5h 23m | AF, HC |
| Milan | BGY | Italy | 4,253 km | 5h 30m | NO |
| Verona | VRN | Italy | 4,300 km | 5h 50m | NO |
| Lille | LIL | France | 4,377 km | 5h 55m | TO |
| Luxembourg | LUX | Luxembourg | 4,416 km | 6h 5m | LG |
| Brussels | BRU | Belgium | 4,460 km | 5h 45m | SN, HC |
| Istanbul | IST | Turkiye | 5,297 km | 6h 50m | TK |
| New York | JFK | USA | 6,165 km | 8h 54m | DL |
| Montreal | YUL | Canada | 6,275 km | 8h 45m | TS |
| Dubai | DXB | United Arab Emirates | 7,589 km | 9h 20m | EK |