Es Senia offers nonstop service to 31 destinations, served by 12 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| El Bayadh | EBH | Algeria | 262 km | 1h 0m | AH |
| Alicante | ALC | Spain | 296 km | 1h 10m | AH, VY |
| Algiers | ALG | Algeria | 363 km | 1h 0m | AH, SF, TB |
| Bechar | CBH | Algeria | 466 km | 2h 0m | AH, SF |
| Ghardaia | GHA | Algeria | 542 km | 1h 18m | AH |
| Constantine | CZL | Algeria | 655 km | 1h 6m | AH |
| Barcelona | BCN | Spain | 672 km | 1h 25m | AH, VY |
| Ouargla | OGX | Algeria | 691 km | 2h 0m | AH |
| Timimoun | TMX | Algeria | 712 km | 2h 15m | AH |
| El Oued | ELU | Algeria | 717 km | 2h 0m | AH |
| Annaba | AAE | Algeria | 768 km | 1h 55m | AH |
| Adrar | AZR | Algeria | 858 km | 1h 25m | AH, SF |
| Toulouse | TLS | France | 905 km | 1h 45m | AH, TO |
| Montpellier | MPL | France | 966 km | 1h 35m | AH, TO |
| Tunis | TUN | Tunisia | 981 km | 1h 50m | TU, BJ |
| Marseille | MRS | France | 1,001 km | 1h 50m | AH, V7, TO |
| Bordeaux | BOD | France | 1,022 km | 2h 0m | AH, V7 |
| Tindouf | TIN | Algeria | 1,132 km | 2h 0m | AH |
| Lyon | LYS | France | 1,219 km | 2h 10m | AH, TO |
| Nantes | NTE | France | 1,284 km | 2h 15m | TO |
| Paris | ORY | France | 1,476 km | 2h 35m | AH, TO |
| Basel, Switzerland/Mulhouse | BSL | France | 1,491 km | 2h 25m | 5O |
| Paris | CDG | France | 1,509 km | 2h 40m | AF, AH |
| Tamanrasset | TMR | Algeria | 1,535 km | 2h 15m | AH |
| Djanet | DJG | Algeria | 1,585 km | 2h 20m | AH |
| Metz/Nancy | ETZ | France | 1,586 km | 2h 20m | AH |
| Lille | LIL | France | 1,687 km | 2h 50m | AH |
| Brussels | BRU | Belgium | 1,745 km | 3h 0m | TB |
| Istanbul | IST | Turkiye | 2,624 km | 4h 5m | AH, TK |
| Madinah | MED | Saudi Arabia | 4,043 km | 5h 15m | AH, SV |
| Jeddah | JED | Saudi Arabia | 4,148 km | 5h 20m | AH, SV |