Zarzis offers nonstop service to 62 destinations, served by 14 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Monastir | MIR | Tunisia | 209 km | 0h 40m | LG, NO, TU |
| Enfidha | NBE | Tunisia | 247 km | 0h 50m | NO |
| Tunis | TUN | Tunisia | 334 km | 0h 55m | TU, UG |
| Rome | FCO | Italy | 888 km | 1h 45m | NO |
| Nice | NCE | France | 1,129 km | 1h 50m | BJ, TU |
| Marseille | MRS | France | 1,166 km | 2h 5m | BJ, TO, TU |
| Bologna | BLQ | Italy | 1,184 km | 2h 0m | NO |
| Montpellier | MPL | France | 1,228 km | 2h 5m | TO |
| Verona | VRN | Italy | 1,280 km | 2h 5m | NO |
| Milan | BGY | Italy | 1,312 km | 2h 15m | NO |
| Milan | MXP | Italy | 1,317 km | 2h 5m | NO |
| Toulouse | TLS | France | 1,355 km | 2h 20m | BJ |
| Lyon | LYS | France | 1,402 km | 2h 25m | BJ, TO, TU |
| Geneva | GVA | Switzerland | 1,428 km | 2h 25m | LX, TU, U2 |
| Berne | BRN | Switzerland | 1,474 km | 2h 15m | 2L |
| Zurich | ZRH | Switzerland | 1,519 km | 2h 35m | WK |
| Basel, Switzerland/Mulhouse | BSL | France | 1,548 km | 2h 35m | BJ, U2 |
| Bordeaux | BOD | France | 1,564 km | 2h 30m | BJ |
| Munich | MUC | Germany | 1,610 km | 2h 35m | 4Y, TU, X3 |
| Strasbourg | SXB | France | 1,650 km | 2h 40m | BJ |
| Stuttgart | STR | Germany | 1,651 km | 2h 35m | X3 |
| Luxembourg | LUX | Luxembourg | 1,790 km | 2h 45m | LG |
| Paris | ORY | France | 1,791 km | 3h 0m | TO, TU |
| Frankfurt | FRA | Germany | 1,805 km | 2h 55m | 4Y, BJ, TU, X3 |
| Nantes | NTE | France | 1,805 km | 3h 0m | BJ, TO |
| Paris | CDG | France | 1,812 km | 3h 0m | BJ, TU |
| Lille | LIL | France | 1,957 km | 3h 0m | BJ |
| Brussels | BRU | Belgium | 1,959 km | 3h 25m | BJ, SN, TB |
| Dusseldorf | DUS | Germany | 1,960 km | 3h 5m | BJ, X3 |
| Hanover | HAJ | Germany | 2,066 km | 3h 5m | X3 |
| London | LTN | United Kingdom | 2,192 km | 3h 25m | U2 |
| Manchester | MAN | United Kingdom | 2,399 km | 3h 45m | U2 |