Felipe Carrillo Puerto Airport offers nonstop service to 13 destinations, served by 10 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Miami | MIA | USA | 979 km | 1h 55m | AA |
| Mexico City | NLU | Mexico | 1,189 km | 2h 14m | VB, AM, XN |
| Mexico City | MEX | Mexico | 1,198 km | 2h 40m | AM |
| Houston | IAH | USA | 1,333 km | 2h 35m | UA |
| Monterrey | MTY | Mexico | 1,418 km | 2h 30m | VB |
| Atlanta | ATL | USA | 1,525 km | 2h 45m | DL |
| Guadalajara | GDL | Mexico | 1,633 km | 2h 49m | Y4 |
| Dallas | DFW | USA | 1,689 km | 3h 13m | AA |
| New York | EWR | USA | 2,610 km | 4h 2m | UA |
| Toronto | YYZ | Canada | 2,712 km | 4h 10m | AC, WS |
| Montreal | YUL | Canada | 3,081 km | 4h 30m | AC, TS, WS |
| Quebec | YQB | Canada | 3,302 km | 4h 25m | TS |
| Calgary | YYC | Canada | 4,135 km | 6h 11m | WS |