Roatan offers nonstop service to 32 destinations, served by 9 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Guanaja | GJA | Honduras | 67 km | 0h 25m | H5 |
| La Ceiba | LCE | Honduras | 73 km | 0h 20m | |
| San Pedro Sula | SAP | Honduras | 177 km | 0h 45m | H5 |
| Belize City | BZE | Belize | 232 km | 1h 0m | 9N |
| Tegucigalpa | TGU | Honduras | 260 km | 0h 55m | H5 |
| San Salvador | SAL | El Salvador | 418 km | 1h 20m | 5U |
| Guatemala City | GUA | Guatemala | 470 km | 1h 20m | 5U |
| Miami | MIA | USA | 1,233 km | 2h 16m | AA |
| Houston | IAH | USA | 1,760 km | 2h 56m | UA |
| Atlanta | ATL | USA | 1,930 km | 3h 15m | DL |
| Dallas | DFW | USA | 2,119 km | 3h 44m | AA |
| Toronto | YYZ | Canada | 3,103 km | 4h 35m | AC, WS |
| Denver | DEN | USA | 3,145 km | 4h 50m | UA |
| Minneapolis | MSP | USA | 3,228 km | 4h 43m | SY |
| Montreal | YUL | Canada | 3,444 km | 4h 45m | AC |
| Quebec | YQB | Canada | 3,657 km | 5h 5m | WS |