Maputo offers nonstop service to 16 destinations, served by 7 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Inhambane | INH | Mozambique | 365 km | 1h 0m | TM |
| Johannesburg | JNB | South Africa | 433 km | 1h 5m | TK, TM, 4Z |
| Durban | DUR | South Africa | 433 km | 1h 10m | QR |
| Vilanculos | VNX | Mozambique | 513 km | 1h 15m | TM |
| Beira | BEW | Mozambique | 719 km | 1h 40m | TM |
| Chimoio | VPY | Mozambique | 755 km | 1h 40m | TM |
| Quelimane | UEL | Mozambique | 997 km | 1h 45m | TM |
| Tete | TET | Mozambique | 1,092 km | 1h 45m | TM |
| Nampula | APL | Mozambique | 1,387 km | 2h 10m | TM |
| Nacala | MNC | Mozambique | 1,523 km | 2h 25m | TM |
| Cape Town | CPT | South Africa | 1,614 km | 2h 50m | 4Z |
| Pemba | POL | Mozambique | 1,656 km | 2h 30m | TM |
| Luanda | NBJ | Angola | 2,747 km | 4h 20m | DT |
| Addis Ababa | ADD | Ethiopia | 3,920 km | 5h 0m | ET |
| Doha | DOH | Qatar | 6,022 km | 8h 5m | QR |
| Lisbon | LIS | Portugal | 8,374 km | 10h 55m | TP |