George Airport offers nonstop service to 6 destinations, served by 3 airlines.
| Destination | Code | Country | Distance | Duration | Airlines |
|---|---|---|---|---|---|
| Cape Town | CPT | South Africa | 349 km | 0h 55m | 4Z, FA |
| Bloemfontein | BFN | South Africa | 658 km | 1h 45m | 5Z |
| Durban | DUR | South Africa | 958 km | 2h 10m | 5Z |
| Johannesburg | JNB | South Africa | 1,038 km | 1h 55m | FA, 5Z, 4Z |
| Lanseria | HLA | South Africa | 1,041 km | 2h 0m | FA |
| Hoedspruit | HDS | South Africa | 1,354 km | 2h 15m | 5Z |